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MLB Prop Bets: Minnesota Twins vs Houston Astros (May 20, 2026)

The Houston Astros (20-30) face the Minnesota Twins (22-27) at Target Field on Wednesday at 1:40pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Mike Burrows is the probable pitcher for the Astros, while Joe Ryan is the probable pitcher for the Twins. The Twins are favored to win at -156, while the Astros are at +129. The total runs line is set at 8.0, with OVER at -112 and UNDER at -108.

  • The Astros (-163) have a 20-30 Run Line record this season, while the Twins (+135) hold a record of 25-24.
  • The Astros have a 28-19-3 O/U record this season (meaning 28 games have gone over the total runs line, 19 have gone under and three have resulted in a push). The Twins have a 27-18-4 O/U record.

Scoring Insights

  • The Astros are averaging 4.3 runs per game this season (15th in the league). Comparatively, the Twins are averaging 4.6 (9th).
  • In the field, the Astros are allowing a whopping 5.4 runs per game this season (28th in the league), while the Twins are allowing an average of 4.7 runs (22nd).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the Astros are at .248 (ranking 6th in the Major leagues), while the Twins are batting .236 (19th).

Home Runs

  • In terms of total home runs this season, the Twins have hit 53 (T11th in the Major Leagues). Meanwhile, the Astros have managed 60 (T6th).

Runs Batted In

  • Finally, looking at their runs batted in, the Astros have recorded 207 RBIs to rank 12th in the MLB this season. Comparatively, the Twins have recorded 213 RBIs to rank 9th.

Pitching Insights:

Earned Run Average

  • The Twins have an earned run average of 4.27 this season (21st in the Majors), while The Astros have an ERA of 5.36 (30th).

Strikeouts

  • Turning our attention to total strikeouts, the Astros have recorded 428 this season, ranking T8th in the MLB. Meanwhile, the Twins rank 27th for total strikeouts, recording 367.

Opponent Batting Average

  • Opponents are batting an average of .244 against the Twins this season (20th in the Major Leagues). Comparatively, the Astros' opponents are at .256 (26th).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Astros 17-13-20 10-6-10 7-7-10 4-4-8 13-9-12 0-0-0 2-2-6
    Twins 11-11-27 9-4-15 2-7-12 2-3-5 9-8-22 0-0-0 2-3-5

Lead After Three Innings

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Astros 18-18-14 10-10-6 8-8-8 6-6-4 12-12-10 0-0-0 3-4-3
    Twins 22-16-11 14-7-7 8-9-4 6-3-1 16-13-10 0-0-0 5-3-2

NRFI/YRFI

  • The NRFI is 19-31 in Astros games this season. The Twins have a 27-22 NRFI record.

Last Time They Met

The Astros recorded a 2-1 victory over the Twins at Target Field yesterday. Isaac Paredes went yard en route to that victory, hitting a home run to go with 2 RBIs.