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MLB Prop Bets: Cleveland Guardians vs Boston Red Sox (May 29, 2026)

The Boston Red Sox (23-32) face the Cleveland Guardians (33-25) at Progressive Field on Friday at 7:10pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Tyler Samaniego is the probable pitcher for the Red Sox, while Slade Cecconi is the probable pitcher for the Guardians. The Guardians are favored to win at -120, while the Red Sox are at -101. The total runs line is set at 8.0, with OVER at -105 and UNDER at -115.

  • The Red Sox (+162) have a 22-33 Run Line record this season, while the Guardians (-197) hold a record of 29-29.
  • The Red Sox have a 25-28-2 O/U record this season (meaning 25 games have gone over the total runs line, 28 have gone under and two have resulted in a push). The Guardians have a 28-30-0 O/U record.

Scoring Insights

  • The Red Sox are averaging 3.8 runs per game this season (28th in the league). Comparatively, the Guardians are averaging 4.1 (19th).
  • In the field, the Red Sox are allowing 4.1 runs per game this season (10th in the league), while the Guardians are allowing an average of 3.9 runs (7th).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the Red Sox are at .244 (ranking 12th in the Major leagues), while the Guardians are batting .230 (25th).

Home Runs

  • In terms of total home runs this season, the Guardians have hit 56 (17th in the Major Leagues). Meanwhile, the Red Sox have managed 42 (29th).

Runs Batted In

  • Finally, looking at their runs batted in, the Red Sox have recorded 200 RBIs to rank 29th in the MLB this season. Comparatively, the Guardians have recorded 230 RBIs to rank T16th.

Pitching Insights:

Earned Run Average

  • The Guardians have an earned run average of 3.64 this season (7th in the Majors), while The Red Sox have an ERA of 3.86 (12th).

Strikeouts

  • Turning our attention to total strikeouts, the Red Sox have recorded 461 this season, ranking 17th in the MLB. Meanwhile, the Guardians rank 1st for total strikeouts, recording 540.

Opponent Batting Average

  • Opponents are batting an average of .235 against the Guardians this season (10th in the Major Leagues). Comparatively, the Red Sox's opponents are at .239 (16th).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Red Sox 6-19-30 3-7-18 3-12-12 3-10-22 3-9-8 0-0-0 2-4-4
    Guardians 11-9-38 6-4-18 5-5-20 6-6-21 5-3-17 0-0-0 0-2-8

Lead After Three Innings

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Red Sox 17-21-17 10-9-9 7-12-8 11-11-13 6-10-4 0-0-0 4-3-3
    Guardians 22-19-17 12-9-7 10-10-10 12-10-11 10-9-6 0-0-0 2-4-4

NRFI/YRFI

  • The NRFI is 28-27 in Red Sox games this season. The Guardians have a 35-23 NRFI record.

Last Time They Met

The Guardians recorded an 8-1 victory over the Red Sox at Fenway Park when these teams last met on September 3, 2025. Steven Kwan went yard en route to that victory, hitting a home run to go with an RBI. That result snapped the Red Sox's four-game winning streak against the Guardians.