MLB Prop Bets: Houston Astros vs Cleveland Guardians (June 21, 2026)
The Cleveland Guardians (41-36) face the Houston Astros (36-42) at Daikin Park on Sunday at 2:10pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Slade Cecconi is the probable pitcher for the Guardians, while Kai-Wei Teng is the probable pitcher for the Astros. The Astros are favored to win at -136, while the Guardians are at +113. The total runs line is set at 8.5, with OVER at -119 and UNDER at -101.
- The Guardians (-181) have a 38-39 Run Line record this season, while the Astros (+149) hold a record of 37-41.
- The Guardians have a 38-39-0 O/U record this season (meaning 38 games have gone over the total runs line and 39 have gone under). The Astros have a 42-33-3 O/U record.
Scoring Insights
- The Guardians are averaging 4.0 runs per game this season (28th in the league). Comparatively, the Astros are averaging +0.5 more at 4.5 runs (14th).
- In the field, the Guardians are allowing 4.1 runs per game this season (8th in the league), while the Astros are allowing an average of 5.1 runs (26th).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the Guardians are at .229 (ranking 28th in the Major leagues), while the Astros are batting .243 (18th).
Home Runs
- In terms of total home runs this season, the Astros have hit 102 (5th in the Major Leagues). Meanwhile, the Guardians have managed 74 (24th).
Runs Batted In
- Finally, looking at their runs batted in, the Guardians have recorded 295 RBIs to rank T26th in the MLB this season. Comparatively, the Astros have recorded 339 RBIs to rank T10th.
Pitching Insights:
Earned Run Average
- The Guardians have one of the strongest earned run averages this season, sitting at 3.81 (6th in the Majors), while the Astros are at the opposite end of the scale with an ERA of 4.89 (28th).
Strikeouts
- Turning our attention to total strikeouts, the Guardians have recorded 707 this season, ranking 3rd in the MLB. Meanwhile, the Astros rank 10th for total strikeouts, recording 671.
Opponent Batting Average
- Opponents are batting an average of .243 against the Astros this season (18th in the Major Leagues). Comparatively, the Guardians' opponents are at .237 (9th).
First Innings Moneyline
- Here are their first innings moneyline records in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Guardians | 16-15-46 | 9-7-20 | 7-8-26 | 10-8-22 | 6-7-24 | 0-0-0 | 2-4-4 |
| Astros | 25-22-31 | 14-10-16 | 11-12-15 | 7-8-11 | 18-14-20 | 0-0-0 | 2-5-3 |
Lead After Three Innings
- Here are their records after the first three innings in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Guardians | 30-23-24 | 17-10-9 | 13-13-15 | 17-11-12 | 13-12-12 | 0-0-0 | 4-2-4 |
| Astros | 29-32-17 | 16-16-8 | 13-16-9 | 9-13-4 | 20-19-13 | 0-0-0 | 2-8-0 |
NRFI/YRFI
The NRFI market is paying -110 and the YRFI is paying -120.
- The NRFI is 43-34 in Guardians games this season. The Astros have a 30-48 NRFI record.
Last Time They Met
The Guardians recorded an upset 8-1 victory over the Astros at Daikin Park yesterday. Travis Bazzana dominated at the plate in that matchup, notching 2 home runs, 2 singles and 5 RBIs.
