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MLB Prop Bets: Arizona Diamondbacks vs St. Louis Cardinals (July 18, 2026)

The St. Louis Cardinals (51-45) face the Arizona Diamondbacks (49-48) at Chase Field on Saturday at 4:10pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Dustin May is the probable pitcher for the Cardinals, while Brandon Pfaadt is the probable pitcher for the Diamondbacks. The Diamondbacks are favored to win at -120, while the Cardinals are at +100. The total runs line is set at 9.0, with OVER at -109 and UNDER at -111.

  • The Cardinals (+161) have a 56-40 Run Line record this season, while the Diamondbacks (-196) hold a record of 54-43.
  • The Cardinals have a 40-52-4 O/U record this season (meaning 40 games have gone over the total runs line, 52 have gone under and four have resulted in a push). The Diamondbacks have a 38-50-9 O/U record.

Scoring Insights

  • The Cardinals are averaging 4.5 runs per game this season (13th in the league). Comparatively, the Diamondbacks are averaging 4.3 (19th).
  • In the field, the Cardinals are allowing 4.4 runs per game this season (14th in the league), while the Diamondbacks are allowing an average of 4.5 runs (16th).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the Cardinals are at .242 (ranking 17th in the Major leagues), while the Diamondbacks are batting .237 (23rd).

Home Runs

  • In terms of total home runs this season, the Diamondbacks have hit 91 (28th in the Major Leagues). Meanwhile, the Cardinals have managed 108 (T20th).

Runs Batted In

  • Finally, looking at their runs batted in, the Cardinals have recorded 422 RBIs to rank 14th in the MLB this season. Comparatively, the Diamondbacks have recorded 401 RBIs to rank 19th.

Pitching Insights:

Earned Run Average

  • The Diamondbacks have an earned run average of 4.20 this season (14th in the Majors), while The Cardinals have an ERA of 4.11 (11th).

Strikeouts

  • Turning our attention to total strikeouts, the Cardinals have recorded 723 this season, ranking 28th in the MLB. Meanwhile, the Diamondbacks rank 30th for total strikeouts, recording 660.

Opponent Batting Average

  • Opponents are batting an average of .249 against the Diamondbacks this season (22nd in the Major Leagues). Comparatively, the Cardinals' opponents are at .251 (23rd).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Cardinals 21-17-58 9-8-35 12-9-23 8-6-14 13-11-44 0-0-0 5-1-4
    Diamondbacks 21-27-49 12-11-23 9-16-24 11-9-19 10-18-30 0-0-2 4-3-3

Lead After Three Innings

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Cardinals 41-27-28 22-13-17 19-14-11 14-7-7 27-20-21 0-0-0 4-3-3
    Diamondbacks 30-45-22 19-14-13 10-30-9 18-10-11 12-35-11 1-1-0 3-3-4

NRFI/YRFI

The NRFI market is paying +100 and the YRFI is paying -130.

  • The NRFI is 50-46 in Cardinals games this season. The Diamondbacks have a 41-56 NRFI record.

Last Time They Met

The Cardinals recorded a 5-4 victory over the Diamondbacks at Chase Field yesterday. That result snapped the Diamondbacks' five-game winning streak against the Cardinals at Chase Field. Tim Tawa was unstoppable in that matchup, hitting a home run, a double and recording an RBI.