MLB Prop Bets: Cleveland Guardians vs Minnesota Twins (July 22, 2026)
The Minnesota Twins (49-53) face the Cleveland Guardians (54-48) at Progressive Field on Wednesday at 6:40pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Bailey Ober is the probable pitcher for the Twins, while Slade Cecconi is the probable pitcher for the Guardians. The Guardians are favored to win at -126, while the Twins are at +104. The total runs line is set at 8.0, with OVER at -106 and UNDER at -114.
- The Twins (-205) have a 54-48 Run Line record this season, while the Guardians (+168) hold a record of 49-53.
- The Twins have a 56-40-6 O/U record this season (meaning 56 games have gone over the total runs line, 40 have gone under and six have resulted in a push). The Guardians have a 48-54-0 O/U record.
Scoring Insights
- The Twins are averaging 4.8 runs per game this season (9th in the league). Comparatively, the Guardians are averaging only 4.0 (29th).
- In the field, the Twins are allowing a whopping 5.1 runs per game this season (26th in the league), while the Guardians are allowing an average of 4.0 runs (8th).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the Twins are at .247 (ranking 11th in the Major leagues), while the Guardians are batting .233 (27th).
Home Runs
- In terms of total home runs this season, the Guardians have hit 101 (T26th in the Major Leagues). Meanwhile, the Twins have managed 124 (12th).
Runs Batted In
- Finally, looking at their runs batted in, the Twins have recorded 462 RBIs to rank 8th in the MLB this season. Comparatively, the Guardians have recorded 392 RBIs to rank 29th.
Pitching Insights:
Earned Run Average
- The Guardians have an earned run average of 3.73 this season (8th in the Majors), while The Twins have an ERA of 4.75 (26th).
Strikeouts
- Turning our attention to total strikeouts, the Twins have recorded 843 this season, ranking T17th in the MLB. Meanwhile, the Guardians rank 4th for total strikeouts, recording 927.
Opponent Batting Average
- Opponents are batting an average of .238 against the Guardians this season (12th in the Major Leagues). Comparatively, the Twins' opponents are at .255 (26th).
First Innings Moneyline
- Here are their first innings moneyline records in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Twins | 26-26-50 | 12-10-29 | 14-16-21 | 7-7-13 | 19-19-37 | 0-0-0 | 2-4-4 |
| Guardians | 21-18-63 | 13-9-29 | 8-9-34 | 13-10-35 | 8-8-28 | 0-0-0 | 2-1-7 |
Lead After Three Innings
- Here are their records after the first three innings in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Twins | 42-39-21 | 21-16-14 | 21-23-7 | 12-8-7 | 30-31-14 | 0-0-0 | 4-5-1 |
| Guardians | 37-31-34 | 22-15-14 | 15-16-20 | 23-18-17 | 14-13-17 | 0-0-0 | 4-2-4 |
NRFI/YRFI
The NRFI market is paying -110 and the YRFI is paying -115.
- The NRFI is 43-59 in Twins games this season. The Guardians have a 60-42 NRFI record.
Last Time They Met
The Guardians recorded an upset 5-2 victory over the Twins at Progressive Field yesterday. Travis Bazzana went yard en route to that victory, hitting a home run to go with an RBI. The Guardians have now won three straight against the Twins.
