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MLB Prop Bets: St. Louis Cardinals vs Baltimore Orioles (August 26, 2026)

The Baltimore Orioles (64-68) face the St. Louis Cardinals (66-67) at Busch Stadium on Wednesday at 7:45pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Kyle Bradish is the probable pitcher for the Orioles, while Michael McGreevy is the probable pitcher for the Cardinals. The Cardinals are favored to win at -112, while the Orioles are at -108. The total runs line is set at 8.0, with OVER at -108 and UNDER at -112.

  • The Orioles (+149) have a 69-63 Run Line record this season, while the Cardinals (-181) hold a record of 71-62.
  • The Orioles have a 65-62-5 O/U record this season (meaning 65 games have gone over the total runs line, 62 have gone under and five have resulted in a push). The Cardinals have a 57-71-5 O/U record.

Scoring Insights

  • The Orioles are averaging 4.5 runs per game this season (14th in the league). Comparatively, the Cardinals are averaging 4.4 (18th).
  • In the field, the Orioles are allowing 4.7 runs per game this season (22nd in the league), while the Cardinals are allowing an average of 4.5 runs (18th).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the Orioles are at .236 (ranking 26th in the Major leagues), while the Cardinals are batting .241 (21st).

Home Runs

  • In terms of total home runs this season, the Cardinals have hit 138 (21st in the Major Leagues). Meanwhile, the Orioles have managed 161 (10th).

Runs Batted In

  • Finally, looking at their runs batted in, the Orioles have recorded 576 RBIs to rank T11th in the MLB this season. Comparatively, the Cardinals have recorded 571 RBIs to rank 14th.

Pitching Insights:

Earned Run Average

  • The Cardinals have an earned run average of 4.21 this season (19th in the Majors), while The Orioles have an ERA of 4.17 (17th).

Strikeouts

  • Turning our attention to total strikeouts, the Orioles have recorded 1048 this season, ranking 23rd in the MLB. Meanwhile, the Cardinals rank 25th for total strikeouts, recording 1028.

Opponent Batting Average

  • Opponents are batting an average of .253 against the Cardinals this season (25th in the Major Leagues). Comparatively, the Orioles' opponents are at .253 (26th).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Orioles 25-26-81 10-10-48 15-16-33 10-8-42 15-18-39 0-0-0 2-0-8
    Cardinals 31-22-80 12-10-45 19-12-35 12-8-23 19-14-57 0-0-0 5-2-3

Lead After Three Innings

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Orioles 43-53-36 24-26-18 19-27-18 19-21-20 24-32-16 0-0-0 1-4-5
    Cardinals 56-39-38 29-18-20 27-21-18 22-11-10 34-28-28 0-0-0 4-4-2

NRFI/YRFI

  • The NRFI is 74-58 in Orioles games this season. The Cardinals have a 71-62 NRFI record.

Last Time They Met

The Orioles recorded a lopsided 13-1 victory against the Cardinals at Busch Stadium yesterday. Pete Alonso dominated at the plate in that matchup, notching 1 home run, 2 singles and 4 RBIs. That result snapped the Cardinals' three-game winning streak against the Orioles at Busch Stadium.