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MLB Prop Bets: Cincinnati Reds vs San Diego Padres (September 2, 2026)

The San Diego Padres (73-66) face the Cincinnati Reds (66-73) at Great American Ball Park on Wednesday at 12:40pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Casey Mize is the probable pitcher for the Padres, while Brandon Williamson is the probable pitcher for the Reds. The Padres are favored to win at -144, while the Reds are at +119. The total runs line is set at 9.5, with OVER at -109 and UNDER at -111.

  • The Padres (+113) have a 73-66 Run Line record this season, while the Reds (-136) hold a record of 71-68.
  • The Padres have a 60-75-4 O/U record this season (meaning 60 games have gone over the total runs line, 75 have gone under and four have resulted in a push). The Reds have a 73-65-1 O/U record.

Scoring Insights

  • The Padres are averaging 4.3 runs per game this season (22nd in the league). Comparatively, the Reds are averaging 4.1 (23rd).
  • In the field, the Padres are allowing 4.2 runs per game this season (9th in the league), while the Reds are allowing an average of 4.9 runs (26th).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the Padres are at .238 (ranking 22nd in the Major leagues), while the Reds are batting .228 (29th).

Home Runs

  • In terms of total home runs this season, the Reds have hit 183 (T4th in the Major Leagues). Meanwhile, the Padres have managed 152 (T19th).

Runs Batted In

  • Finally, looking at their runs batted in, the Padres have recorded 569 RBIs to rank T19th in the MLB this season. Comparatively, the Reds have recorded 550 RBIs to rank 23rd.

Pitching Insights:

Earned Run Average

  • The Reds have an earned run average of 4.66 this season (26th in the Majors), while The Padres have an ERA of 3.91 (9th).

Strikeouts

  • Turning our attention to total strikeouts, the Padres have recorded 1124 this season, ranking 20th in the MLB. Meanwhile, the Reds rank 21st for total strikeouts, recording 1119.

Opponent Batting Average

  • Opponents are batting an average of .252 against the Reds this season (24th in the Major Leagues). Comparatively, the Padres' opponents are at .241 (16th).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Padres 23-26-90 13-13-43 10-13-45 15-10-41 8-16-49 0-0-2 0-2-8
    Reds 28-40-71 13-16-41 15-24-30 11-10-21 17-30-50 0-0-0 1-5-4

Lead After Three Innings

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Padres 45-57-37 26-27-16 18-29-21 21-23-22 24-34-15 1-1-0 2-3-5
    Reds 40-56-43 21-23-26 19-33-17 15-14-13 25-42-30 0-0-0 2-5-3

NRFI/YRFI

  • The NRFI is 85-54 in Padres games this season. The Reds have a 67-72 NRFI record.

Last Time They Met

The Reds recorded a 4-3 victory over the Padres at Great American Ball Park yesterday. Fernando Tatis Jr. was crushing the ball in that matchup, hitting 2 home runs and recording 2 RBIs.