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MLB Prop Bets: St. Louis Cardinals vs Chicago White Sox (September 13, 2026)

The Chicago White Sox (76-72) face the St. Louis Cardinals (73-76) at Busch Stadium on Sunday at 2:15pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Sean Burke is the probable pitcher for the White Sox, while Michael McGreevy is the probable pitcher for the Cardinals.

  • The White Sox have an 83-63-2 O/U record this season (meaning 83 games have gone over the total runs line, 63 have gone under and two have resulted in a push). The Cardinals have a 69-74-6 O/U record.

Scoring Insights

  • The White Sox are averaging 4.7 runs per game this season (7th in the league). Comparatively, the Cardinals are averaging 4.6 (10th).
  • In the field, the White Sox are allowing 4.4 runs per game this season (15th in the league), while the Cardinals are allowing an average of 4.6 runs (T20th).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the White Sox are at .235 (ranking 26th in the Major leagues), while the Cardinals are batting .244 (16th).

Home Runs

  • In terms of total home runs this season, the Cardinals have hit 157 (T21st in the Major Leagues). Meanwhile, the White Sox have managed 193 (6th).

Runs Batted In

  • Finally, looking at their runs batted in, the White Sox have recorded 662 RBIs to rank 7th in the MLB this season. Comparatively, the Cardinals have recorded 660 RBIs to rank 8th.

Pitching Insights:

Earned Run Average

  • The Cardinals have an earned run average of 4.31 this season (21st in the Majors), while The White Sox have an ERA of 4.16 (14th).

Strikeouts

  • Turning our attention to total strikeouts, the White Sox have recorded 1224 this season, ranking 17th in the MLB. Meanwhile, the Cardinals rank 24th for total strikeouts, recording 1179.

Opponent Batting Average

  • Opponents are batting an average of .254 against the Cardinals this season (25th in the Major Leagues). Comparatively, the White Sox's opponents are at .242 (15th).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    White Sox 36-39-73 19-18-37 17-21-36 9-6-27 27-33-46 0-0-0 2-2-6
    Cardinals 32-30-87 12-12-50 20-18-37 12-13-25 20-17-62 0-0-0 1-6-3

Lead After Three Innings

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    White Sox 51-53-44 27-23-24 24-30-20 13-9-20 38-44-24 0-0-0 2-4-4
    Cardinals 65-45-39 33-20-21 32-25-18 26-13-11 39-32-28 0-0-0 6-4-0

NRFI/YRFI

  • The NRFI is 67-81 in White Sox games this season. The Cardinals have a 77-72 NRFI record.

Last Time They Met

The White Sox recorded a 6-5 victory over the Cardinals at Busch Stadium yesterday. Randal Grichuk went yard en route to that victory, hitting a home run to go with 2 RBIs. That result snapped the Cardinals' four-game winning streak against the White Sox.