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MLB Prop Bets: St. Louis Cardinals vs Washington Nationals (September 20, 2026)

The Washington Nationals (73-82) face the St. Louis Cardinals (75-80) at Busch Stadium on Sunday at 2:15pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Jake Irvin is the probable pitcher for the Nationals, while Quinn Mathews is the probable pitcher for the Cardinals. The Cardinals are favored to win at -149, while the Nationals are at +123. The total runs line is set at 9.0, with OVER at -109 and UNDER at -110.

  • The Nationals (-168) have an 88-67 Run Line record this season, while the Cardinals (+139) hold a record of 83-72.
  • The Nationals have an 82-66-7 O/U record this season (meaning 82 games have gone over the total runs line, 66 have gone under and seven have resulted in a push). The Cardinals have a 73-76-6 O/U record.

Scoring Insights

  • The Nationals are averaging 5.1 runs per game this season (3rd in the league). Comparatively, the Cardinals are averaging 4.5 (12th).
  • In the field, the Nationals are allowing a whopping 5.0 runs per game this season (27th in the league), while the Cardinals are allowing an average of 4.7 runs (22nd).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the Nationals are at .247 (ranking 11th in the Major leagues), while the Cardinals are batting .243 (19th).

Home Runs

  • In terms of total home runs this season, the Nationals are one of the best in the Major Leagues, hitting 202 to rank 5th. Alternatively, the Cardinals are at the opposite end of the home run standings, hitting just 158 (25th).

Runs Batted In

  • Finally, looking at their runs batted in, the Nationals have recorded 753 RBIs to rank 3rd in the MLB this season. Comparatively, the Cardinals have recorded 676 RBIs to rank 10th.

Pitching Insights:

Earned Run Average

  • The Cardinals have an earned run average of 4.30 this season (22nd in the Majors), while The Nationals have an ERA of 4.66 (26th).

Strikeouts

  • Turning our attention to total strikeouts, the Nationals have recorded 1219 this season, ranking 25th in the MLB. Meanwhile, the Cardinals rank 24th for total strikeouts, recording 1230.

Opponent Batting Average

  • Opponents are batting an average of .254 against the Cardinals this season (26th in the Major Leagues). Comparatively, the Nationals' opponents are at .253 (25th).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Nationals 42-33-80 24-12-42 18-21-38 15-5-19 27-28-61 0-0-0 4-3-3
    Cardinals 32-33-90 12-15-53 20-18-37 12-14-27 20-19-63 0-0-0 0-5-5

Lead After Three Innings

The Nationals are +114 to lead after three innings, while the Cardinals are -145.

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Nationals 62-51-42 36-19-23 26-32-19 21-6-12 41-45-30 0-0-0 4-4-2
    Cardinals 65-50-40 33-25-22 32-25-18 26-15-12 39-35-28 0-0-0 3-6-1

NRFI/YRFI

The NRFI market is paying -110 and the YRFI is paying -120.

  • The NRFI is 77-78 in Nationals games this season. The Cardinals have an 80-75 NRFI record.

Last Time They Met

The Nationals recorded an 8-5 extra innings victory over the Cardinals at Busch Stadium yesterday. Daylen Lile went yard en route to that victory, hitting a home run to go with 2 RBIs.