NFL Prop Bets: San Francisco 49ers vs Tennessee Titans - Week 15

The Tennessee Titans (2-11) face the San Francisco 49ers (9-4) at Levi's Stadium for Week 15. Let's take a look at the NFL Prop Bets for Sunday's matchup. The 49ers are favored to win at -910, currently marked as 12.5-point favorites, while the Titans are at +600.

The total points line is set at 44.5, with OVER at -110 and UNDER at -110, meaning the implied expected score for the game is 28-16 San Francisco.

  • The Titans (-113) have a 6-7-0 ATS record this season, while the 49ers (-108) hold a record of 8-5-0.
  • The Titans have an 8-5-0 O/U record this season (meaning eight games have gone over the total points line and five have gone under). The 49ers have a 7-5-1 O/U record.

Points on the board

  • The Titans are averaging 15.5 points per game this season (31st in the league). Comparatively, the 49ers are performing better, averaging 23.6 (16th).
  • Defensively, the Titans are giving up a whopping 27.5 points per game this season (29th in the league), while the 49ers are giving up an average of 20.7 points (8th).

Moving the chains

  • With an average of just 246.2, the Titans rank 32nd in the league for total yards per game. Comparatively, the 49ers rank 12th with 341.2 yards per game.
  • In terms of yards allowed, the Titans are giving up 350.9 per game this season (26th in the league), while the 49ers are giving up an average of 335.8 (20th).

Ascendency in the air

  • The Titans have recorded 161.3 passing yards per game this season (31st in the league). Comparatively, the 49ers' defense has given up 232.0 passing yards per game (25th).
  • Meanwhile, the 49ers have recorded 242.6 passing yards per game this season (6th in the league), while the Titans' defense has given up 228.5 passing yards per game (23rd).

Advantage on the ground

  • Looking at the ground game, the Titans have recorded 84.9 rushing yards per game this season (31st in the league). Conversely, the 49ers are giving up 103.8 rushing yards per game (12th).
  • On the other hand, the 49ers have recorded 98.5 rushing yards per game this season (25th in the league), while the Titans are giving up 122.5 rushing yards per game (18th).

Protecting the ball

  • Looking at their ability to force turnovers, the Titans have recorded 12 total takeaways this season (T25th in the league), while the 49ers have recorded 14 (T20th).
  • On offense, the Titans have recorded 17 total giveaways this season (T17th in the league), while the 49ers have recorded 18 (T23rd).

First to Score

The Titans are +160 to score first, while the 49ers are -210.

  • The Titans have scored first in seven of their 13 games this season.
  • The 49ers have also scored first in seven of their 13 games.

Which team will score the first touchdown?

The Titans are +250 to record the first touchdown, while the 49ers are -323.

  • The Titans have recorded the first touchdown in three of their 13 games this season.
  • The 49ers have recorded the first touchdown in eight of their 13 games this season.

First Scoring Play

    Play Frequency Odds
    Tennessee Touchdown2 / 13+521
    Tennessee Field Goal5 / 13+356
    Tennessee Safety0 / 13+6400
    San Francisco Touchdown6 / 13+125
    San Francisco Field Goal1 / 13+298
    San Francisco Safety0 / 13+7300

Which team will get a quick start?

The Titans are +312 to be the first team to reach 10 points, while the 49ers are -400.

  • The Titans have been the first to score 10 points in three of their 13 games this season.
  • The 49ers have been the first to score 10 points in nine of their 13 games this season.

First Quarter Moneyline

The 49ers are favored in the 1st Quarter Moneyline market, currently at -286, while the Titans are +230.

  • The Titans have a 4-7-2 first quarter W/L/T record this season, while the 49ers hold a record of 7-3-3.

Last Time They Met

The Titans recorded a 20-17 victory over the 49ers at Nissan Stadium when these teams last met in Week 16, 2021.

NFL Injury News – Tennessee Titans vs San Francisco 49ers December 14, 2025

Tennessee Titans - Injury Report
Kevin Zeitler (NIR - Rest) – Questionable

NIR - Rest

Dan Moore (Neck) – Questionable

Neck

Lloyd Cushenberry (Foot) – Questionable

Foot

James Williams (Illness) – Questionable

Illness

Jalyn Armour-Davis (Achilles) – Out

Achilles

C.J. Ravenell (Toe) – Questionable

Toe

San Francisco 49ers - Injury Report
Yetur Gross-Matos (Hamstring) – Out

Hamstring

Nickolas Martin (Concussion) – Out

Concussion

Sam Okuayinonu (Ankle) – Out

Ankle

Tatum Bethune (Ankle) – Out

Ankle

Kurtis Rourke (Knee) – Out

Knee