MLB Prop Bets: St. Louis Cardinals vs Cleveland Guardians (April 15, 2026)
The Cleveland Guardians (10-8) face the St. Louis Cardinals (9-8) at Busch Stadium on Wednesday at 1:15pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Slade Cecconi is the probable pitcher for the Guardians, while Dustin May is the probable pitcher for the Cardinals. The total runs line is set at 8.5, with OVER at -108 and UNDER at -112.
- The Guardians (+145) have a 10-8 Run Line record this season, while the Cardinals (-177) hold a record of 9-8.
- The Guardians have a 9-9-0 O/U record this season (meaning nine games have gone over the total runs line and nine have gone under). The Cardinals have a 10-7-0 O/U record.
Scoring Insights
- The Guardians are averaging 4.0 runs per game this season (T21st in the league). Comparatively, the Cardinals are averaging 4.4 (14th).
- In the field, the Guardians are allowing 4.2 runs per game this season (13th in the league), while the Cardinals are allowing an average of 5.5 runs (27th).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the Guardians are at .228 (ranking 21st in the Major leagues), while the Cardinals are batting .227 (22nd).
Home Runs
- In terms of total home runs this season, the Cardinals have hit 20 (T5th in the Major Leagues). Meanwhile, the Guardians have managed 19 (T9th).
Runs Batted In
- Finally, looking at their runs batted in, the Guardians have recorded 67 RBIs to rank T20th in the MLB this season. Comparatively, the Cardinals have recorded 74 RBIs to rank 11th.
Pitching Insights:
Earned Run Average
- The Cardinals have an earned run average of 5.05 this season (28th in the Majors), while The Guardians have an ERA of 3.98 (14th).
Strikeouts
- Turning our attention to total strikeouts, the Guardians have recorded an impressive 174 this season, ranking 3rd in the MLB. Contrastingly, the Cardinals rank 30th for total strikeouts, recording only 103.
Opponent Batting Average
- Opponents are batting an average of .265 against the Cardinals this season (28th in the Major Leagues). Comparatively, the Guardians' opponents are at .233 (16th).
First Innings Moneyline
- Here are their first innings moneyline records in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Guardians | 3-0-15 | 1-0-5 | 2-0-10 | 0-0-4 | 3-0-11 | 0-0-0 | 2-0-8 |
| Cardinals | 2-3-12 | 1-1-9 | 1-2-3 | 0-1-1 | 2-2-11 | 0-0-0 | 1-3-6 |
Lead After Three Innings
- Here are their records after the first three innings in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Guardians | 6-7-5 | 2-3-1 | 4-4-4 | 1-1-2 | 5-6-3 | 0-0-0 | 3-4-3 |
| Cardinals | 5-5-7 | 4-2-5 | 1-3-2 | 1-1-0 | 4-4-7 | 0-0-0 | 2-4-4 |
NRFI/YRFI
The NRFI market is paying -120 and the YRFI is paying -105.
- The NRFI is 12-6 in Guardians games this season. The Cardinals have a 9-8 NRFI record.
Last Time They Met
The Cardinals recorded a 6-5 extra innings victory over the Guardians at Busch Stadium yesterday. JJ Wetherholt was crushing the ball in that matchup, hitting 2 home runs and recording 3 RBIs.
