MLB Prop Bets: San Diego Padres vs Seattle Mariners (April 16, 2026)

The Seattle Mariners (8-11) face the San Diego Padres (12-6) at Petco Park on Thursday at 8:40pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Luis Castillo is the probable pitcher for the Mariners, while Walker Buehler is the probable pitcher for the Padres. The Mariners are favored to win at -120, while the Padres are at +100. The total runs line is set at 8.0, with OVER at -112 and UNDER at -108.

• The Mariners (+139) have a 9-10 Run Line record this season, while the Padres (-168) hold a record of 11-7.
• The Mariners have a 9-10-0 O/U record this season (meaning nine games have gone over the total runs line and 10 have gone under). The Padres have a 9-8-1 O/U record.

Scoring Insights

• The Mariners are averaging 4.0 runs per game this season (T20th in the league). Comparatively, the Padres are averaging 4.7 (11th).
• In the field, the Mariners are allowing only 3.6 runs per game this season (6th in the league), while the Padres are allowing an average of 3.7 runs (7th).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

• Looking at their batting averages this season, the Mariners are at .209 (ranking 28th in the Major leagues), while the Padres are batting .236 (16th).

Home Runs

• In terms of total home runs this season, the Padres have hit 17 (T17th in the Major Leagues). Meanwhile, the Mariners have managed 17 (T17th).

Runs Batted In

• Finally, looking at their runs batted in, the Mariners have recorded 73 RBIs to rank 18th in the MLB this season. Comparatively, the Padres have recorded 80 RBIs to rank 13th.

Pitching Insights:

Earned Run Average

• The Padres have an earned run average of 3.42 this season (7th in the Majors), while The Mariners have an ERA of 3.24 (3rd).

Strikeouts

• Turning our attention to total strikeouts, the Mariners have recorded 159 this season, ranking T12th in the MLB. Meanwhile, the Padres rank 9th for total strikeouts, recording 170.

Opponent Batting Average

• Opponents are batting an average of .234 against the Padres this season (14th in the Major Leagues). Comparatively, the Mariners' opponents are at .234 (15th).

First Innings Moneyline

• Here are their first innings moneyline records in 2026.

	Total	Home	Road	Favorite	Underdog	Neutral	Last 10
Mariners	5-5-9	4-3-4	1-2-5	5-4-6	0-1-3	0-0-0	5-1-4
Padres	2-3-13	2-3-7	0-0-6	2-1-7	0-2-6	0-0-0	1-1-8

Lead After Three Innings

• Here are their records after the first three innings in 2026.

	Total	Home	Road	Favorite	Underdog	Neutral	Last 10
Mariners	7-6-6	5-4-2	2-2-4	5-5-5	2-1-1	0-0-0	4-2-4
Padres	5-7-6	4-5-3	1-2-3	3-3-4	2-4-2	0-0-0	2-3-5

NRFI/YRFI

The NRFI market is paying -125 and the YRFI is paying -105.

• The NRFI is 7-12 in Mariners games this season. The Padres have a 13-5 NRFI record.

Last Time They Met

The Padres recorded a 7-6 victory over the Mariners at Petco Park yesterday. Luke Raley dominated at the plate in that matchup, notching 1 home run, 2 singles and 2 RBIs.