MLB Prop Bets: Los Angeles Angels vs St. Louis Cardinals (July 22, 2026)
The St. Louis Cardinals (51-49) face the Los Angeles Angels (41-61) at Angel Stadium of Anaheim on Wednesday at 4:07pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Hunter Dobbins is the probable pitcher for the Cardinals, while Reid Detmers is the probable pitcher for the Angels. The Angels are favored to win at -132, while the Cardinals are at +110. The total runs line is set at 8.5, with OVER at -117 and UNDER at -103.
- The Cardinals (-187) have a 57-43 Run Line record this season, while the Angels (+153) hold a record of 51-51.
- The Cardinals have a 41-55-4 O/U record this season (meaning 41 games have gone over the total runs line, 55 have gone under and four have resulted in a push). The Angels have a 46-54-2 O/U record.
Scoring Insights
- The Cardinals are averaging 4.5 runs per game this season (15th in the league). Comparatively, the Angels are averaging 4.3 (19th).
- In the field, the Cardinals are allowing 4.5 runs per game this season (15th in the league), while the Angels are allowing an average of 4.9 runs (24th).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the Cardinals are at .241 (ranking 18th in the Major leagues), while the Angels are batting .240 (20th).
Home Runs
- In terms of total home runs this season, the Angels have hit 112 (T20th in the Major Leagues). Meanwhile, the Cardinals have managed 109 (22nd).
Runs Batted In
- Finally, looking at their runs batted in, the Cardinals have recorded 435 RBIs to rank 14th in the MLB this season. Comparatively, the Angels have recorded 426 RBIs to rank 18th.
Pitching Insights:
Earned Run Average
- The Angels have an earned run average of 4.56 this season (23rd in the Majors), while The Cardinals have an ERA of 4.16 (12th).
Strikeouts
- Turning our attention to total strikeouts, the Cardinals have recorded 754 this season, ranking 28th in the MLB. Meanwhile, the Angels rank 8th for total strikeouts, recording 898.
Opponent Batting Average
- Opponents are batting an average of .237 against the Angels this season (8th in the Major Leagues). Comparatively, the Cardinals' opponents are at .251 (23rd).
First Innings Moneyline
- Here are their first innings moneyline records in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Cardinals | 21-18-61 | 9-8-35 | 12-10-26 | 8-6-15 | 13-12-46 | 0-0-0 | 4-1-5 |
| Angels | 28-22-52 | 18-8-25 | 10-14-27 | 6-2-13 | 22-20-39 | 0-0-0 | 3-4-3 |
Lead After Three Innings
The Cardinals are +110 to lead after three innings, while the Angels are -140.
- Here are their records after the first three innings in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Cardinals | 43-29-28 | 22-13-17 | 21-16-11 | 15-7-7 | 28-22-21 | 0-0-0 | 4-3-3 |
| Angels | 35-41-26 | 21-15-15 | 14-26-11 | 11-8-2 | 24-33-24 | 0-0-0 | 3-6-1 |
NRFI/YRFI
The NRFI market is paying -115 and the YRFI is paying -115.
- The NRFI is 53-47 in Cardinals games this season. The Angels have a 47-55 NRFI record.
Last Time They Met
The Angels recorded a 5-1 victory over the Cardinals at Angel Stadium of Anaheim yesterday. Jo Adell was unstoppable in that matchup, hitting a home run, a single and recording 2 RBIs. The Angels have now won three straight at Angel Stadium of Anaheim against the Cardinals.
