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MLB Prop Bets: San Diego Padres vs Chicago Cubs (September 30, 2026)

The Chicago Cubs face the San Diego Padres at Petco Park in the MLB League Wild Card Round on Wednesday at 10:00pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Kevin Gausman is the probable pitcher for the Cubs, while Nick Pivetta is the probable pitcher for the Padres. The Padres are favored to win at -145, while the Cubs are at +120. The total runs line is set at 7.0, with OVER at -124 and UNDER at +103.

  • The Cubs (-184) have a 79-84 Run Line record since the beginning of the regular season, while the Padres (+152) hold a record of 86-77.
  • The Cubs have a 90-68-5 O/U record since the beginning of the regular season (meaning 90 games have gone over the total runs line, 68 have gone under and five have resulted in a push). The Padres have a 76-81-6 O/U record.

Scoring Insights

  • The Cubs are averaging 5.2 runs per game during the regular season (1st in the league). Comparatively, the Padres are averaging only 4.5 (16th).
  • In the field, the Cubs are allowing 4.3 runs per game during the regular season (12th in the league), while the Padres are allowing an average of 4.2 runs (9th).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages during the regular season, the Cubs are at .251 (ranking 6th in the Major leagues), while the Padres are batting .244 (17th).

Home Runs

  • In terms of total home runs during the regular season, the Padres have hit 183 (T14th in the Major Leagues). Meanwhile, the Cubs have managed 220 (3rd).

Runs Batted In

  • Finally, looking at their runs batted in, the Cubs have recorded 804 RBIs to rank 1st in the MLB during the regular season. Comparatively, the Padres have recorded 696 RBIs to rank T14th.

Pitching Insights:

Earned Run Average

  • The Padres have an earned run average of 3.99 during the regular season (10th in the Majors), while The Cubs have an ERA of 4.12 (14th).

Strikeouts

  • Turning our attention to total strikeouts, the Cubs have recorded 1260 during the regular season, ranking 26th in the MLB. Meanwhile, the Padres rank 20th for total strikeouts, recording 1315.

Opponent Batting Average

  • Opponents are batting an average of .242 against the Padres during the regular season (15th in the Major Leagues). Comparatively, the Cubs' opponents are at .243 (16th).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026 (including playoffs).
    Total Home Road Favorite Underdog Neutral Last 10
    Cubs 39-33-91 25-16-40 13-17-51 34-19-62 5-14-29 1-0-0 3-2-5
    Padres 31-30-102 17-14-51 14-16-49 23-13-48 8-17-54 0-0-2 2-1-7

Lead After Three Innings

The Cubs are +100 to lead after three innings, while the Padres are -130.

  • Here are their records after the first three innings in 2026 (including playoffs).
    Total Home Road Favorite Underdog Neutral Last 10
    Cubs 66-50-47 41-21-19 24-29-28 56-29-30 10-21-17 1-0-0 4-3-3
    Padres 57-64-42 33-32-17 23-31-25 32-28-24 25-36-18 1-1-0 4-4-2

NRFI/YRFI

The NRFI market is paying -130 and the YRFI is paying +100.

  • The NRFI is 86-77 in Cubs games during the regular season. The Padres have a 96-67 NRFI record.

Last Time They Met

The Padres recorded a lopsided 8-0 victory against the Cubs at Petco Park yesterday. Fernando Tatis Jr. was unstoppable in that matchup, hitting a home run, a single and recording an RBI. That result snapped the Cubs' five-game winning streak against the Padres.