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MLB Prop Bets: Chicago White Sox vs Washington Nationals (April 25, 2026)

The Washington Nationals (11-16) face the Chicago White Sox (11-15) at Rate Field on Saturday at 4:10pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Jake Irvin is the probable pitcher for the Nationals, while Noah Schultz is the probable pitcher for the White Sox. The White Sox are favored to win at -143, while the Nationals are at +119. The total runs line is set at 8.5, with OVER at -122 and UNDER at +102.

  • The Nationals (-175) have a 15-12 Run Line record this season, while the White Sox (+144) hold a record of 12-14.
  • The Nationals have an 18-8-1 O/U record this season (meaning 18 games have gone over the total runs line, eight have gone under and one has resulted in a push). The White Sox have a 16-10-0 O/U record.

Scoring Insights

  • The Nationals are averaging 5.5 runs per game this season (3rd in the league). Comparatively, the White Sox are averaging only 4.2 (19th).
  • In the field, the Nationals are allowing a whopping 6.2 runs per game this season (30th in the league), while the White Sox are allowing an average of 5.2 runs (26th).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the Nationals are at .250 (ranking 10th in the Major leagues), while the White Sox are batting .227 (25th).

Home Runs

  • In terms of total home runs this season, the White Sox have hit 33 (T6th in the Major Leagues). Meanwhile, the Nationals have managed 33 (T6th).

Runs Batted In

  • Finally, looking at their runs batted in, the Nationals have recorded 136 RBIs to rank 2nd in the MLB this season. Comparatively, the White Sox have recorded 99 RBIs to rank T23rd.

Pitching Insights:

Earned Run Average

  • The White Sox have an earned run average of 4.84 this season (27th in the Majors), while The Nationals have an ERA of 5.67 (29th).

Strikeouts

  • Turning our attention to total strikeouts, the Nationals have recorded 203 this season, ranking 25th in the MLB. Meanwhile, the White Sox rank 27th for total strikeouts, recording 198.

Opponent Batting Average

  • Opponents are batting an average of .249 against the White Sox this season (19th in the Major Leagues). Comparatively, the Nationals' opponents are at .272 (29th).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Nationals 11-5-11 7-2-4 4-3-7 0-1-0 11-4-11 0-0-0 5-1-4
    White Sox 9-5-12 3-1-6 6-4-6 0-0-1 9-5-11 0-0-0 4-2-4

Lead After Three Innings

The Nationals are +110 to lead after three innings, while the White Sox are -140.

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Nationals 10-12-5 6-5-2 4-7-3 0-0-1 10-12-4 0-0-0 5-3-2
    White Sox 12-9-5 5-3-2 7-6-3 0-1-0 12-8-5 0-0-0 5-4-1

NRFI/YRFI

The NRFI market is paying -120 and the YRFI is paying -110.

  • The NRFI is 11-16 in Nationals games this season. The White Sox have a 12-14 NRFI record.

Last Time They Met

The White Sox recorded a 5-4 victory over the Nationals at Rate Field yesterday. Munetaka Murakami went yard en route to that victory, hitting a home run to go with an RBI. The White Sox have now won three straight at Rate Field against the Nationals.