MLB Prop Bets: Arizona Diamondbacks vs San Diego Padres (April 25, 2026)
The San Diego Padres (17-8) face the Arizona Diamondbacks (14-11) at Estadio Alfredo Harp Helú on Saturday at 6:05pm (ET). Let's take a look at the MLB Prop Bets for the matchup. German Marquez is the probable pitcher for the Padres, while Zac Gallen is the probable pitcher for the Diamondbacks. The Diamondbacks are favored to win at -118, while the Padres are at -102. The total runs line is set at 15.5, with OVER at -106 and UNDER at -114.
- The Padres (-154) have a 14-11 Run Line record this season, while the Diamondbacks (+127) hold a record of 17-8.
- The Padres have a 10-14-1 O/U record this season (meaning 10 games have gone over the total runs line, 14 have gone under and one has resulted in a push). The Diamondbacks have a 14-9-2 O/U record.
Scoring Insights
- The Padres are averaging 4.4 runs per game this season (17th in the league). Comparatively, the Diamondbacks are averaging 4.6 (14th).
- In the field, the Padres are allowing only 3.8 runs per game this season (5th in the league), while the Diamondbacks are allowing an average of 5.0 runs (23rd).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the Padres are at .234 (ranking 17th in the Major leagues), while the Diamondbacks are batting .251 (9th).
Home Runs
- In terms of total home runs this season, the Diamondbacks have hit 23 (22nd in the Major Leagues). Meanwhile, the Padres have managed 20 (25th).
Runs Batted In
- Finally, looking at their runs batted in, the Padres have recorded 105 RBIs to rank 20th in the MLB this season. Comparatively, the Diamondbacks have recorded 110 RBIs to rank 17th.
Pitching Insights:
Earned Run Average
- The Diamondbacks have an earned run average of 4.41 this season (20th in the Majors), while The Padres have an ERA of 3.62 (7th).
Strikeouts
- Turning our attention to total strikeouts, the Padres have recorded 230 this season, ranking T9th in the MLB. Meanwhile, the Diamondbacks rank 29th for total strikeouts, recording 188.
Opponent Batting Average
- Opponents are batting an average of .251 against the Diamondbacks this season (22nd in the Major Leagues). Comparatively, the Padres' opponents are at .240 (16th).
First Innings Moneyline
- Here are their first innings moneyline records in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Padres | 3-4-18 | 2-3-8 | 1-1-10 | 3-2-10 | 0-2-8 | 0-0-0 | 2-1-7 |
| Diamondbacks | 7-7-11 | 3-4-6 | 4-3-5 | 2-2-3 | 5-5-8 | 0-0-0 | 2-3-5 |
Lead After Three Innings
The Padres are -110 to lead after three innings, while the Diamondbacks are -120.
- Here are their records after the first three innings in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Padres | 6-10-9 | 5-5-3 | 1-5-6 | 3-5-7 | 3-5-2 | 0-0-0 | 3-4-3 |
| Diamondbacks | 8-10-7 | 4-4-5 | 4-6-2 | 3-1-3 | 5-9-4 | 0-0-0 | 3-3-4 |
NRFI/YRFI
The NRFI market is paying +170 and the YRFI is paying -220.
- The NRFI is 18-7 in Padres games this season. The Diamondbacks have a 9-16 NRFI record.
Last Time They Met
The Padres recorded a lopsided 12-4 victory against the Diamondbacks at Petco Park when these teams last met on September 28, 2025. Jackson Merrill went yard en route to that victory, hitting a home run to go with 3 RBIs. The Padres have now won five straight against the Diamondbacks.
