MLB Prop Bets: St. Louis Cardinals vs Seattle Mariners (April 25, 2026)
The Seattle Mariners (12-15) face the St. Louis Cardinals (14-11) at Busch Stadium on Saturday at 2:15pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Bryan Woo is the probable pitcher for the Mariners, while Matthew Liberatore is the probable pitcher for the Cardinals. The Mariners are favored to win at -149, while the Cardinals are at +123. The total runs line is set at 7.5, with OVER at -110 and UNDER at -110.
- The Mariners (+113) have an 11-16 Run Line record this season, while the Cardinals (-136) hold a record of 15-10.
- The Mariners have a 12-15-0 O/U record this season (meaning 12 games have gone over the total runs line and 15 have gone under). The Cardinals have a 13-12-0 O/U record.
Scoring Insights
- The Mariners are averaging 3.9 runs per game this season (25th in the league). Comparatively, the Cardinals are averaging +0.7 more at 4.6 runs (15th).
- In the field, the Mariners are allowing only 3.7 runs per game this season (4th in the league), while the Cardinals are allowing an average of 5.0 runs (24th).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the Mariners are at .223 (ranking 28th in the Major leagues), while the Cardinals are batting .230 (21st).
Home Runs
- In terms of total home runs this season, the Cardinals have hit 27 (T16th in the Major Leagues). Meanwhile, the Mariners have managed 26 (T18th).
Runs Batted In
- Finally, looking at their runs batted in, the Mariners have recorded 101 RBIs to rank 22nd in the MLB this season. Comparatively, the Cardinals have recorded 111 RBIs to rank 16th.
Pitching Insights:
Earned Run Average
- The Mariners have one of the strongest earned run averages this season, sitting at 3.37 (4th in the Majors), while the Cardinals are at the opposite end of the scale with an ERA of 4.70 (26th).
Strikeouts
- Turning our attention to total strikeouts, the Mariners have recorded 222 this season, ranking 15th in the MLB. Meanwhile, the Cardinals rank 30th for total strikeouts, recording 164.
Opponent Batting Average
- Opponents are batting an average of .252 against the Cardinals this season (23rd in the Major Leagues). Comparatively, the Mariners' opponents are at .254 (26th).
First Innings Moneyline
- Here are their first innings moneyline records in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Mariners | 8-8-11 | 7-6-4 | 1-2-7 | 8-7-8 | 0-1-3 | 0-0-0 | 3-3-4 |
| Cardinals | 4-4-17 | 1-2-10 | 3-2-7 | 0-2-1 | 4-2-16 | 0-0-0 | 2-1-7 |
Lead After Three Innings
The Mariners are -166 to lead after three innings, while the Cardinals are +130.
- Here are their records after the first three innings in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Mariners | 11-9-7 | 8-6-3 | 3-3-4 | 9-8-6 | 2-1-1 | 0-0-0 | 5-4-1 |
| Cardinals | 8-8-9 | 4-3-6 | 4-5-3 | 1-1-1 | 7-7-8 | 0-0-0 | 3-3-4 |
NRFI/YRFI
The NRFI market is paying -140 and the YRFI is paying +105.
- The NRFI is 9-18 in Mariners games this season. The Cardinals have a 13-12 NRFI record.
Last Time They Met
The Mariners recorded a 3-2 victory over the Cardinals at Busch Stadium yesterday. Josh Naylor went yard en route to that victory, hitting a home run to go with an RBI. The Mariners have now won five straight against the Cardinals.
