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MLB Prop Bets: Chicago White Sox vs Minnesota Twins (May 25, 2026)

The Minnesota Twins (26-27) face the Chicago White Sox (26-26) at Rate Field on Monday at 2:10pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Zebby Matthews is the probable pitcher for the Twins, while Anthony Kay is the probable pitcher for the White Sox. The Twins are favored to win at -114, while the White Sox are at -106. The total runs line is set at 8.0, with OVER at -113 and UNDER at -106.

  • The Twins (+144) have a 29-24 Run Line record this season, while the White Sox (-175) hold a record of 28-24.
  • The Twins have a 29-20-4 O/U record this season (meaning 29 games have gone over the total runs line, 20 have gone under and four have resulted in a push). The White Sox have a 31-20-1 O/U record.

Scoring Insights

  • The Twins are averaging 4.7 runs per game this season (9th in the league). Comparatively, the White Sox are averaging 4.5 (12th).
  • In the field, the Twins are allowing 4.6 runs per game this season (23rd in the league), while the White Sox are allowing an average of 4.8 runs (24th).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the Twins are at .240 (ranking 16th in the Major leagues), while the White Sox are batting .232 (23rd).

Home Runs

  • In terms of total home runs this season, the White Sox have hit 70 (3rd in the Major Leagues). Meanwhile, the Twins have managed 57 (14th).

Runs Batted In

  • Finally, looking at their runs batted in, the Twins have recorded 234 RBIs to rank T6th in the MLB this season. Comparatively, the White Sox have recorded 223 RBIs to rank T13th.

Pitching Insights:

Earned Run Average

  • The White Sox have an earned run average of 4.54 this season (24th in the Majors), while The Twins have an ERA of 4.19 (18th).

Strikeouts

  • Turning our attention to total strikeouts, the Twins have recorded 407 this season, ranking 25th in the MLB. Meanwhile, the White Sox rank T22nd for total strikeouts, recording 419.

Opponent Batting Average

  • Opponents are batting an average of .243 against the White Sox this season (20th in the Major Leagues). Comparatively, the Twins' opponents are at .242 (17th).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Twins 13-12-28 9-4-16 4-8-12 2-3-6 11-9-22 0-0-0 3-3-4
    White Sox 14-13-25 7-6-11 7-7-14 0-1-6 14-12-19 0-0-0 2-5-3

Lead After Three Innings

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Twins 24-17-12 14-7-8 10-10-4 6-3-2 18-14-10 0-0-0 6-3-1
    White Sox 21-17-14 11-7-6 10-10-8 0-3-4 21-14-10 0-0-0 2-4-4

NRFI/YRFI

The NRFI market is paying -115 and the YRFI is paying -115.

  • The NRFI is 28-25 in Twins games this season. The White Sox have a 24-28 NRFI record.

Last Time They Met

The White Sox recorded an 11-8 victory over the Twins at Target Field when these teams last met on September 4, 2025. Kyle Teel was unstoppable in that matchup, hitting a home run, a double and recording 4 RBIs. The White Sox have now won six straight against the Twins.