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MLB Prop Bets: St. Louis Cardinals vs Cincinnati Reds (June 5, 2026)

The Cincinnati Reds (31-30) face the St. Louis Cardinals (32-28) at Busch Stadium on Friday at 8:15pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Brady Singer is the probable pitcher for the Reds, while Kyle Leahy is the probable pitcher for the Cardinals. The Cardinals are favored to win at -137, while the Reds are at +114. The total runs line is set at 9.0, with OVER at -118 and UNDER at -102.

  • The Reds (-175) have a 34-27 Run Line record this season, while the Cardinals (+144) hold a record of 37-23.
  • The Reds have a 37-24-0 O/U record this season (meaning 37 games have gone over the total runs line and 24 have gone under). The Cardinals have a 26-32-2 O/U record.

Scoring Insights

  • The Reds are averaging 4.3 runs per game this season (15th in the league). Comparatively, the Cardinals are averaging 4.3 (17th).
  • In the field, the Reds are allowing 5.0 runs per game this season (24th in the league), while the Cardinals are allowing an average of 4.5 runs (16th).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the Reds are at .229 (ranking 27th in the Major leagues), while the Cardinals are batting .240 (17th).

Home Runs

  • In terms of total home runs this season, the Cardinals have hit 65 (16th in the Major Leagues). Meanwhile, the Reds have managed 77 (8th).

Runs Batted In

  • Finally, looking at their runs batted in, the Reds have recorded 249 RBIs to rank 21st in the MLB this season. Comparatively, the Cardinals have recorded 250 RBIs to rank 20th.

Pitching Insights:

Earned Run Average

  • The Cardinals have an earned run average of 4.14 this season (17th in the Majors), while The Reds have an ERA of 4.76 (27th).

Strikeouts

  • Turning our attention to total strikeouts, the Reds have recorded 476 this season, ranking 26th in the MLB. Meanwhile, the Cardinals rank 27th for total strikeouts, recording 465.

Opponent Batting Average

  • Opponents are batting an average of .254 against the Cardinals this season (25th in the Major Leagues). Comparatively, the Reds' opponents are at .249 (21st).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Reds 11-18-32 6-8-18 5-10-14 5-4-11 6-14-21 0-0-0 1-4-5
    Cardinals 10-11-39 5-5-22 5-6-17 3-3-4 7-8-35 0-0-0 2-1-7

Lead After Three Innings

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Reds 18-28-15 9-15-8 9-13-7 7-8-5 11-20-10 0-0-0 3-5-2
    Cardinals 24-17-19 14-8-10 10-9-9 6-3-1 18-14-18 0-0-0 4-2-4

NRFI/YRFI

The NRFI market is paying -105 and the YRFI is paying -125.

  • The NRFI is 30-31 in Reds games this season. The Cardinals have a 33-27 NRFI record.

Last Time They Met

The Reds recorded a 7-6 extra innings victory over the Cardinals at Great American Ball Park when these teams last met on May 23. Jordan Walker was unstoppable in that matchup, hitting a home run, a double and recording 4 RBIs.