MLB Prop Bets: Chicago White Sox vs Cleveland Guardians (June 22, 2026)
The Cleveland Guardians (41-37) face the Chicago White Sox (39-37) at Rate Field on Monday at 7:40pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Gavin Williams is the probable pitcher for the Guardians, while Anthony Kay is the probable pitcher for the White Sox. The Guardians are favored to win at -114, while the White Sox are at -105. The total runs line is set at 7.5, with OVER at -119 and UNDER at -101.
- The Guardians (+144) have a 39-39 Run Line record this season, while the White Sox (-175) hold a record of 41-35.
- The Guardians have a 38-40-0 O/U record this season (meaning 38 games have gone over the total runs line and 40 have gone under). The White Sox have a 44-30-2 O/U record.
Scoring Insights
- The Guardians are averaging 4.0 runs per game this season (28th in the league). Comparatively, the White Sox are averaging +0.7 more at 4.6 runs (12th).
- In the field, the Guardians are allowing 4.1 runs per game this season (8th in the league), while the White Sox are allowing an average of 4.7 runs (19th).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the Guardians are at .228 (ranking 29th in the Major leagues), while the White Sox are batting .237 (23rd).
Home Runs
- In terms of total home runs this season, the White Sox are one of the best in the Major Leagues, hitting 106 to rank 2nd. Alternatively, the Guardians are at the opposite end of the home run standings, hitting just 74 (25th).
Runs Batted In
- Finally, looking at their runs batted in, the Guardians have recorded 296 RBIs to rank 28th in the MLB this season. Comparatively, the White Sox have recorded 337 RBIs to rank T14th.
Pitching Insights:
Earned Run Average
- The White Sox have an earned run average of 4.41 this season (20th in the Majors), while The Guardians have an ERA of 3.79 (6th).
Strikeouts
- Turning our attention to total strikeouts, the Guardians have recorded 710 this season, ranking 4th in the MLB. Meanwhile, the White Sox rank 19th for total strikeouts, recording 619.
Opponent Batting Average
- Opponents are batting an average of .242 against the White Sox this season (17th in the Major Leagues). Comparatively, the Guardians' opponents are at .237 (8th).
First Innings Moneyline
- Here are their first innings moneyline records in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Guardians | 16-16-46 | 9-7-20 | 7-9-26 | 10-8-22 | 6-8-24 | 0-0-0 | 2-4-4 |
| White Sox | 21-22-33 | 10-11-15 | 11-11-18 | 2-3-9 | 19-19-24 | 0-0-0 | 3-4-3 |
Lead After Three Innings
- Here are their records after the first three innings in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Guardians | 30-24-24 | 17-10-9 | 13-14-15 | 17-11-12 | 13-13-12 | 0-0-0 | 4-3-3 |
| White Sox | 29-28-19 | 15-13-8 | 14-15-11 | 5-5-4 | 24-23-15 | 0-0-0 | 1-6-3 |
NRFI/YRFI
The NRFI market is paying -130 and the YRFI is paying +100.
- The NRFI is 43-35 in Guardians games this season. The White Sox have a 31-45 NRFI record.
Last Time They Met
The Guardians recorded a 3-2 victory over the White Sox at Progressive Field when these teams last met on September 14, 2025. Bo Naylor was unstoppable in that matchup, hitting a home run, a double and recording 3 RBIs. The Guardians have now won seven straight at Progressive Field against the White Sox.
