MLB Prop Bets: St. Louis Cardinals vs Arizona Diamondbacks (June 22, 2026)
The Arizona Diamondbacks (39-38) face the St. Louis Cardinals (41-34) at Busch Stadium on Monday at 7:45pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Merrill Kelly is the probable pitcher for the Diamondbacks, while Andre Pallante is the probable pitcher for the Cardinals. The Cardinals are favored to win at -144, while the Diamondbacks are at +119. The total runs line is set at 8.5, with OVER at -111 and UNDER at -108.
- The Diamondbacks (-168) have a 43-34 Run Line record this season, while the Cardinals (+139) hold a record of 46-29.
- The Diamondbacks have a 31-39-7 O/U record this season (meaning 31 games have gone over the total runs line, 39 have gone under and seven have resulted in a push). The Cardinals have a 34-38-3 O/U record.
Scoring Insights
- The Diamondbacks are averaging 4.3 runs per game this season (18th in the league). Comparatively, the Cardinals are averaging 4.7 (11th).
- In the field, the Diamondbacks are allowing 4.6 runs per game this season (18th in the league), while the Cardinals are allowing an average of 4.6 runs (17th).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the Diamondbacks are at .239 (ranking 22nd in the Major leagues), while the Cardinals are batting .249 (9th).
Home Runs
- In terms of total home runs this season, the Cardinals have hit 87 (16th in the Major Leagues). Meanwhile, the Diamondbacks have managed 68 (T27th).
Runs Batted In
- Finally, looking at their runs batted in, the Diamondbacks have recorded 319 RBIs to rank 17th in the MLB this season. Comparatively, the Cardinals have recorded 337 RBIs to rank T14th.
Pitching Insights:
Earned Run Average
- The Cardinals have an earned run average of 4.29 this season (18th in the Majors), while The Diamondbacks have an ERA of 4.30 (19th).
Strikeouts
- Turning our attention to total strikeouts, the Diamondbacks have recorded 536 this season, ranking 30th in the MLB. Meanwhile, the Cardinals rank 28th for total strikeouts, recording 575.
Opponent Batting Average
- Opponents are batting an average of .256 against the Cardinals this season (25th in the Major Leagues). Comparatively, the Diamondbacks' opponents are at .251 (21st).
First Innings Moneyline
- Here are their first innings moneyline records in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Diamondbacks | 15-22-40 | 8-10-21 | 7-12-17 | 9-8-18 | 6-14-22 | 0-0-2 | 1-4-5 |
| Cardinals | 15-14-46 | 5-7-26 | 10-7-20 | 6-5-9 | 9-9-37 | 0-0-0 | 4-2-4 |
Lead After Three Innings
- Here are their records after the first three innings in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Diamondbacks | 25-38-14 | 15-14-10 | 9-23-4 | 16-10-9 | 9-28-5 | 1-1-0 | 2-6-2 |
| Cardinals | 32-20-23 | 15-10-13 | 17-10-10 | 10-5-5 | 22-15-18 | 0-0-0 | 6-2-2 |
NRFI/YRFI
The NRFI market is paying -120 and the YRFI is paying -110.
- The NRFI is 34-43 in Diamondbacks games this season. The Cardinals have a 39-36 NRFI record.
Last Time They Met
The Diamondbacks recorded a 5-3 victory over the Cardinals at Chase Field when these teams last met on July 20, 2025. Eugenio Suarez was crushing the ball in that matchup, hitting 2 home runs and recording 4 RBIs. The Diamondbacks have now won five straight at Chase Field against the Cardinals.
