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MLB Prop Bets: Minnesota Twins vs Cleveland Guardians (September 12, 2026)

The Cleveland Guardians (75-73) face the Minnesota Twins (69-78) at Target Field on Saturday at 4:10pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Gavin Williams is the probable pitcher for the Guardians, while Connor Prielipp is the probable pitcher for the Twins.

  • The Guardians have a 70-77-1 O/U record this season (meaning 70 games have gone over the total runs line, 77 have gone under and one has resulted in a push). The Twins have a 78-59-10 O/U record.

Scoring Insights

  • The Guardians are averaging 4.1 runs per game this season (27th in the league). Comparatively, the Twins are averaging +0.5 more at 4.6 runs (8th).
  • In the field, the Guardians are allowing 4.2 runs per game this season (9th in the league), while the Twins are allowing an average of 5.0 runs (26th).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the Guardians are at .237 (ranking 24th in the Major leagues), while the Twins are batting .245 (15th).

Home Runs

  • In terms of total home runs this season, the Twins have hit 172 (13th in the Major Leagues). Meanwhile, the Guardians have managed 139 (30th).

Runs Batted In

  • Finally, looking at their runs batted in, the Guardians have recorded 578 RBIs to rank 27th in the MLB this season. Comparatively, the Twins have recorded 647 RBIs to rank 10th.

Pitching Insights:

Earned Run Average

  • The Twins have an earned run average of 4.67 this season (26th in the Majors), while The Guardians have an ERA of 3.79 (8th).

Strikeouts

  • Turning our attention to total strikeouts, the Guardians have recorded 1391 this season, ranking 3rd in the MLB. Meanwhile, the Twins rank 16th for total strikeouts, recording 1233.

Opponent Batting Average

  • Opponents are batting an average of .251 against the Twins this season (23rd in the Major Leagues). Comparatively, the Guardians' opponents are at .237 (10th).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Guardians 33-26-89 19-13-43 14-13-46 23-17-54 10-9-35 0-0-0 2-4-4
    Twins 36-40-71 18-12-42 18-27-29 12-11-24 24-29-47 0-1-0 2-3-5

Lead After Three Innings

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Guardians 52-50-46 32-24-19 20-26-27 36-32-26 16-18-20 0-0-0 2-8-0
    Twins 58-60-29 32-22-18 26-37-11 20-16-11 38-44-18 0-1-0 3-5-2

NRFI/YRFI

  • The NRFI is 83-65 in Guardians games this season. The Twins have a 59-88 NRFI record.

Last Time They Met

The Guardians recorded a 5-2 victory over the Twins at Target Field yesterday. Angel Martinez was unstoppable in that matchup, hitting a home run, a double and recording 2 RBIs.