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MLB Prop Bets: Cleveland Guardians vs Chicago White Sox (September 14, 2026)

The Chicago White Sox (76-73) face the Cleveland Guardians (76-74) at Progressive Field on Monday at 6:40pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Sean Newcomb is the probable pitcher for the White Sox, while Gavin Williams is the probable pitcher for the Guardians. The Guardians are favored to win at -149, while the White Sox are at +124. The total runs line is set at 7.0, with OVER at -102 and UNDER at -118.

  • The White Sox (-186) have an 81-68 Run Line record this season, while the Guardians (+153) hold a record of 68-82.
  • The White Sox have an 83-64-2 O/U record this season (meaning 83 games have gone over the total runs line, 64 have gone under and two have resulted in a push). The Guardians have a 71-78-1 O/U record.

Scoring Insights

  • The White Sox are averaging 4.7 runs per game this season (7th in the league). Comparatively, the Guardians are averaging only 4.1 (27th).
  • In the field, the White Sox are allowing 4.4 runs per game this season (15th in the league), while the Guardians are allowing an average of 4.1 runs (9th).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the White Sox are at .235 (ranking 26th in the Major leagues), while the Guardians are batting .237 (24th).

Home Runs

  • In terms of total home runs this season, the White Sox are one of the best in the Major Leagues, hitting 193 to rank 6th. Alternatively, the Guardians are at the opposite end of the home run standings, hitting just 142 (30th).

Runs Batted In

  • Finally, looking at their runs batted in, the White Sox have recorded 663 RBIs to rank T7th in the MLB this season. Comparatively, the Guardians have recorded 590 RBIs to rank T27th.

Pitching Insights:

Earned Run Average

  • The Guardians have an earned run average of 3.78 this season (8th in the Majors), while The White Sox have an ERA of 4.13 (14th).

Strikeouts

  • Turning our attention to total strikeouts, the White Sox have recorded 1233 this season, ranking 17th in the MLB. Meanwhile, the Guardians rank 3rd for total strikeouts, recording 1415.

Opponent Batting Average

  • Opponents are batting an average of .236 against the Guardians this season (10th in the Major Leagues). Comparatively, the White Sox's opponents are at .242 (15th).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    White Sox 36-39-74 19-18-37 17-21-37 9-6-28 27-33-46 0-0-0 2-2-6
    Guardians 34-26-90 19-13-43 15-13-47 23-17-54 11-9-36 0-0-0 3-3-4

Lead After Three Innings

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    White Sox 52-53-44 27-23-24 25-30-20 14-9-20 38-44-24 0-0-0 3-4-3
    Guardians 53-51-46 32-24-19 21-27-27 36-32-26 17-19-20 0-0-0 2-8-0

NRFI/YRFI

  • The NRFI is 68-81 in White Sox games this season. The Guardians have an 84-66 NRFI record.

Last Time They Met

The White Sox recorded a 5-3 victory over the Guardians at Rate Field when these teams last met on August 9. Colson Montgomery went yard en route to that victory, hitting a home run to go with 3 RBIs.