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MLB Prop Bets: St. Louis Cardinals vs San Francisco Giants (September 14, 2026)

The San Francisco Giants (62-88) face the St. Louis Cardinals (74-76) at Busch Stadium on Monday at 7:45pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Landen Roupp is the probable pitcher for the Giants, while Quinn Mathews is the probable pitcher for the Cardinals.

  • The Giants have a 71-66-13 O/U record this season (meaning 71 games have gone over the total runs line, 66 have gone under and 13 have resulted in a push). The Cardinals have a 69-75-6 O/U record.

Scoring Insights

  • The Giants are averaging 4.2 runs per game this season (24th in the league). Comparatively, the Cardinals are averaging +0.3 more at 4.6 runs (11th).
  • In the field, the Giants are allowing 4.7 runs per game this season (23rd in the league), while the Cardinals are allowing an average of 4.6 runs (20th).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the Giants are at .247 (ranking 12th in the Major leagues), while the Cardinals are batting .243 (16th).

Home Runs

  • In terms of total home runs this season, the Cardinals have hit 157 (22nd in the Major Leagues). Meanwhile, the Giants have managed 172 (16th).

Runs Batted In

  • Finally, looking at their runs batted in, the Giants have recorded 611 RBIs to rank 23rd in the MLB this season. Comparatively, the Cardinals have recorded 663 RBIs to rank T7th.

Pitching Insights:

Earned Run Average

  • The Cardinals have an earned run average of 4.29 this season (21st in the Majors), while The Giants have an ERA of 4.39 (23rd).

Strikeouts

  • Turning our attention to total strikeouts, the Giants have recorded 1121 this season, ranking 27th in the MLB. Meanwhile, the Cardinals rank 24th for total strikeouts, recording 1188.

Opponent Batting Average

  • Opponents are batting an average of .254 against the Cardinals this season (24th in the Major Leagues). Comparatively, the Giants' opponents are at .249 (19th).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Giants 39-36-75 23-10-42 16-26-33 11-6-29 28-30-46 0-0-0 6-3-1
    Cardinals 32-30-88 12-12-51 20-18-37 12-13-25 20-17-63 0-0-0 1-5-4

Lead After Three Innings

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Giants 50-61-39 25-27-23 25-34-16 16-15-15 34-46-24 0-0-0 3-5-2
    Cardinals 65-46-39 33-21-21 32-25-18 26-13-11 39-33-28 0-0-0 6-4-0

NRFI/YRFI

  • The NRFI is 72-78 in Giants games this season. The Cardinals have a 78-72 NRFI record.

Last Time They Met

The Giants recorded a 7-6 victory over the Cardinals at Oracle Park on Wednesday. Despite being on the wrong side of that result, Leo Bernal went yard in that matchup, hitting a home run to go with 3 RBIs. The Giants have now won four straight against the Cardinals.