MLB Prop Bets: Cleveland Guardians vs Chicago White Sox (September 15, 2026)
The Chicago White Sox (77-73) face the Cleveland Guardians (76-75) at Progressive Field on Tuesday at 6:40pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Davis Martin is the probable pitcher for the White Sox, while Foster Griffin is the probable pitcher for the Guardians. The Guardians are favored to win at -130, while the White Sox are at +108. The total runs line is set at 8.5, with OVER at -108 and UNDER at -112.
- The White Sox (-194) have an 82-68 Run Line record this season, while the Guardians (+159) hold a record of 68-83.
- The White Sox have an 84-64-2 O/U record this season (meaning 84 games have gone over the total runs line, 64 have gone under and two have resulted in a push). The Guardians have a 72-78-1 O/U record.
Scoring Insights
- The White Sox are averaging 4.7 runs per game this season (7th in the league). Comparatively, the Guardians are averaging only 4.1 (27th).
- In the field, the White Sox are allowing 4.4 runs per game this season (14th in the league), while the Guardians are allowing an average of 4.2 runs (9th).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the White Sox are at .235 (ranking 26th in the Major leagues), while the Guardians are batting .237 (24th).
Home Runs
- In terms of total home runs this season, the White Sox are one of the best in the Major Leagues, hitting 194 to rank 6th. Alternatively, the Guardians are at the opposite end of the home run standings, hitting just 143 (30th).
Runs Batted In
- Finally, looking at their runs batted in, the White Sox have recorded 669 RBIs to rank 7th in the MLB this season. Comparatively, the Guardians have recorded 592 RBIs to rank 28th.
Pitching Insights:
Earned Run Average
- The Guardians have an earned run average of 3.79 this season (8th in the Majors), while The White Sox have an ERA of 4.11 (12th).
Strikeouts
- Turning our attention to total strikeouts, the White Sox have recorded 1240 this season, ranking 17th in the MLB. Meanwhile, the Guardians rank 3rd for total strikeouts, recording 1429.
Opponent Batting Average
- Opponents are batting an average of .237 against the Guardians this season (T10th in the Major Leagues). Comparatively, the White Sox's opponents are at .241 (15th).
First Innings Moneyline
- Here are their first innings moneyline records in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| White Sox | 36-39-75 | 19-18-37 | 17-21-38 | 9-6-28 | 27-33-47 | 0-0-0 | 2-1-7 |
| Guardians | 34-26-91 | 19-13-44 | 15-13-47 | 23-17-55 | 11-9-36 | 0-0-0 | 3-2-5 |
Lead After Three Innings
The White Sox are +105 to lead after three innings, while the Guardians are -135.
- Here are their records after the first three innings in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| White Sox | 52-53-45 | 27-23-24 | 25-30-21 | 14-9-20 | 38-44-25 | 0-0-0 | 3-3-4 |
| Guardians | 53-51-47 | 32-24-20 | 21-27-27 | 36-32-27 | 17-19-20 | 0-0-0 | 2-7-1 |
NRFI/YRFI
The NRFI market is paying -105 and the YRFI is paying -120.
- The NRFI is 69-81 in White Sox games this season. The Guardians have an 85-66 NRFI record.
Last Time They Met
The White Sox recorded an upset 7-3 victory over the Guardians at Progressive Field yesterday. Miguel Vargas was unstoppable in that matchup, hitting a home run, a single and recording 2 RBIs. The White Sox have now won three straight against the Guardians.
