MLB Prop Bets: St. Louis Cardinals vs San Francisco Giants (September 15, 2026)
The San Francisco Giants (62-89) face the St. Louis Cardinals (75-76) at Busch Stadium on Tuesday at 7:45pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Blade Tidwell is the probable pitcher for the Giants, while Andre Pallante is the probable pitcher for the Cardinals. The Cardinals are favored to win at -168, while the Giants are at +138. The total runs line is set at 8.0, with OVER at -119 and UNDER at -101.
- The Giants (-155) have a 77-74 Run Line record this season, while the Cardinals (+129) hold a record of 83-68.
- The Giants have a 71-67-13 O/U record this season (meaning 71 games have gone over the total runs line, 67 have gone under and 13 have resulted in a push). The Cardinals have a 69-76-6 O/U record.
Scoring Insights
- The Giants are averaging 4.2 runs per game this season (24th in the league). Comparatively, the Cardinals are averaging +0.3 more at 4.5 runs (12th).
- In the field, the Giants are allowing 4.7 runs per game this season (23rd in the league), while the Cardinals are allowing an average of 4.6 runs (20th).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the Giants are at .247 (ranking 12th in the Major leagues), while the Cardinals are batting .243 (17th).
Home Runs
- In terms of total home runs this season, the Cardinals have hit 157 (22nd in the Major Leagues). Meanwhile, the Giants have managed 172 (16th).
Runs Batted In
- Finally, looking at their runs batted in, the Giants have recorded 612 RBIs to rank 23rd in the MLB this season. Comparatively, the Cardinals have recorded 665 RBIs to rank 9th.
Pitching Insights:
Earned Run Average
- The Cardinals have an earned run average of 4.27 this season (21st in the Majors), while The Giants have an ERA of 4.38 (23rd).
Strikeouts
- Turning our attention to total strikeouts, the Giants have recorded 1127 this season, ranking 27th in the MLB. Meanwhile, the Cardinals rank 24th for total strikeouts, recording 1200.
Opponent Batting Average
- Opponents are batting an average of .253 against the Cardinals this season (24th in the Major Leagues). Comparatively, the Giants' opponents are at .249 (19th).
First Innings Moneyline
- Here are their first innings moneyline records in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Giants | 39-36-76 | 23-10-42 | 16-26-34 | 11-6-29 | 28-30-47 | 0-0-0 | 6-2-2 |
| Cardinals | 32-30-89 | 12-12-52 | 20-18-37 | 12-13-26 | 20-17-63 | 0-0-0 | 0-5-5 |
Lead After Three Innings
The Giants are +124 to lead after three innings, while the Cardinals are -160.
- Here are their records after the first three innings in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Giants | 50-61-40 | 25-27-23 | 25-34-17 | 16-15-15 | 34-46-25 | 0-0-0 | 3-4-3 |
| Cardinals | 65-46-40 | 33-21-22 | 32-25-18 | 26-13-12 | 39-33-28 | 0-0-0 | 5-4-1 |
NRFI/YRFI
The NRFI market is paying -105 and the YRFI is paying -120.
- The NRFI is 73-78 in Giants games this season. The Cardinals have a 79-72 NRFI record.
Last Time They Met
The Cardinals recorded an upset 2-1 victory over the Giants at Busch Stadium yesterday. Leo Bernal went yard en route to that victory, hitting a home run to go with an RBI. That result snapped the Giants' four-game winning streak against the Cardinals.
