MLB Prop Bets: San Francisco Giants vs Minnesota Twins (September 21, 2026)
The Minnesota Twins (73-83) face the San Francisco Giants (64-92) at Oracle Park on Monday at 9:45pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Zebby Matthews is the probable pitcher for the Twins, while Blade Tidwell is the probable pitcher for the Giants. The Twins are favored to win at -118, while the Giants are at -102. The total runs line is set at 8.0, with OVER at -118 and UNDER at -102.
- The Twins (+144) have an 83-73 Run Line record this season, while the Giants (-175) hold a record of 79-77.
- The Twins have an 84-61-11 O/U record this season (meaning 84 games have gone over the total runs line, 61 have gone under and 11 have resulted in a push). The Giants have a 75-68-13 O/U record.
Scoring Insights
- The Twins are averaging 4.6 runs per game this season (10th in the league). Comparatively, the Giants are averaging only 4.2 (T23rd).
- In the field, the Twins are allowing a whopping 5.0 runs per game this season (26th in the league), while the Giants are allowing an average of 4.7 runs (23rd).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the Twins are at .244 (ranking 14th in the Major leagues), while the Giants are batting .247 (11th).
Home Runs
- In terms of total home runs this season, the Giants have hit 177 (17th in the Major Leagues). Meanwhile, the Twins have managed 180 (13th).
Runs Batted In
- Finally, looking at their runs batted in, the Twins have recorded 681 RBIs to rank T9th in the MLB this season. Comparatively, the Giants have recorded 633 RBIs to rank 23rd.
Pitching Insights:
Earned Run Average
- The Giants have an earned run average of 4.39 this season (23rd in the Majors), while The Twins have an ERA of 4.60 (25th).
Strikeouts
- Turning our attention to total strikeouts, the Twins have recorded 1325 this season, ranking 13th in the MLB. Meanwhile, the Giants rank 27th for total strikeouts, recording 1159.
Opponent Batting Average
- Opponents are batting an average of .249 against the Giants this season (22nd in the Major Leagues). Comparatively, the Twins' opponents are at .249 (21st).
First Innings Moneyline
- Here are their first innings moneyline records in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Twins | 38-43-75 | 19-14-44 | 19-28-31 | 13-12-26 | 25-31-49 | 0-1-0 | 2-3-5 |
| Giants | 41-38-77 | 23-10-42 | 18-28-35 | 11-6-29 | 30-32-48 | 0-0-0 | 5-3-2 |
Lead After Three Innings
The Twins are -120 to lead after three innings, while the Giants are -110.
- Here are their records after the first three innings in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Twins | 63-64-29 | 34-25-18 | 29-38-11 | 23-17-11 | 40-47-18 | 0-1-0 | 6-4-0 |
| Giants | 54-62-40 | 25-27-23 | 29-35-17 | 16-15-15 | 38-47-25 | 0-0-0 | 4-4-2 |
NRFI/YRFI
The NRFI market is paying -125 and the YRFI is paying -105.
- The NRFI is 63-93 in Twins games this season. The Giants have a 74-82 NRFI record.
Last Time They Met
The Twins recorded a 7-6 extra innings victory over the Giants at Target Field when these teams last met on May 11, 2025. Heliot Ramos was unstoppable in that matchup, hitting a home run, a single and recording 4 RBIs. The Twins have now won four straight at Target Field against the Giants.
