MLB Prop Bets: Pittsburgh Pirates vs St. Louis Cardinals (September 23, 2026)
The St. Louis Cardinals (76-81) face the Pittsburgh Pirates (80-77) at PNC Park on Wednesday at 6:40pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Matthew Liberatore is the probable pitcher for the Cardinals, while Lake Bachar is the probable pitcher for the Pirates.
- The Cardinals have a 73-78-6 O/U record this season (meaning 73 games have gone over the total runs line, 78 have gone under and six have resulted in a push). The Pirates have an 80-70-7 O/U record.
Scoring Insights
- The Cardinals are averaging 4.5 runs per game this season (12th in the league). Comparatively, the Pirates are averaging 4.8 (5th).
- In the field, the Cardinals are allowing 4.6 runs per game this season (22nd in the league), while the Pirates are allowing an average of 4.6 runs (20th).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the Cardinals are at .241 (ranking 20th in the Major leagues), while the Pirates are batting .254 (5th).
Home Runs
- In terms of total home runs this season, the Pirates have hit 181 (13th in the Major Leagues). Meanwhile, the Cardinals have managed 161 (T24th).
Runs Batted In
- Finally, looking at their runs batted in, the Cardinals have recorded 681 RBIs to rank 12th in the MLB this season. Comparatively, the Pirates have recorded 716 RBIs to rank 5th.
Pitching Insights:
Earned Run Average
- The Pirates have an earned run average of 4.16 this season (16th in the Majors), while The Cardinals have an ERA of 4.28 (22nd).
Strikeouts
- Turning our attention to total strikeouts, the Pirates have recorded an impressive 1443 this season, ranking 5th in the MLB. Contrastingly, the Cardinals rank 25th for total strikeouts, recording only 1239.
Opponent Batting Average
- Opponents are batting an average of .237 against the Pirates this season (9th in the Major Leagues). Comparatively, the Cardinals' opponents are at .253 (26th).
First Innings Moneyline
- Here are their first innings moneyline records in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Cardinals | 33-33-91 | 13-15-53 | 20-18-38 | 13-14-27 | 20-19-64 | 0-0-0 | 1-3-6 |
| Pirates | 41-29-87 | 23-15-41 | 18-14-46 | 25-12-43 | 16-17-44 | 0-0-0 | 2-3-5 |
Lead After Three Innings
- Here are their records after the first three innings in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Cardinals | 66-50-41 | 34-25-22 | 32-25-19 | 27-15-12 | 39-35-29 | 0-0-0 | 3-5-2 |
| Pirates | 61-55-41 | 38-21-20 | 23-34-21 | 37-23-20 | 24-32-21 | 0-0-0 | 3-6-1 |
NRFI/YRFI
- The NRFI is 81-76 in Cardinals games this season. The Pirates have an 83-74 NRFI record.
Last Time They Met
The Pirates recorded an upset 2-0 victory over the Cardinals at PNC Park yesterday. Konnor Griffin led the way to that victory, hitting a home run. That result snapped the Cardinals' four-game winning streak against the Pirates at PNC Park.
