home team icon
away team icon

MLB Prop Bets: Boston Red Sox vs Cleveland Guardians (September 23, 2026)

The Cleveland Guardians (82-75) face the Boston Red Sox (84-73) at Fenway Park on Wednesday at 7:10pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Foster Griffin is the probable pitcher for the Guardians, while Sonny Gray is the probable pitcher for the Red Sox. The Red Sox are favored to win at -132, while the Guardians are at +109. The total runs line is set at 7.5, with OVER at +104 and UNDER at -126.

  • The Guardians (-198) have a 72-85 Run Line record this season, while the Red Sox (+163) hold a record of 74-83.
  • The Guardians have a 75-80-2 O/U record this season (meaning 75 games have gone over the total runs line, 80 have gone under and two have resulted in a push). The Red Sox have a 70-83-4 O/U record.

Scoring Insights

  • The Guardians are averaging 4.2 runs per game this season (26th in the league). Comparatively, the Red Sox are averaging 4.3 (20th).
  • In the field, the Guardians are allowing 4.1 runs per game this season (8th in the league), while the Red Sox are allowing an average of 3.8 runs (3rd).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the Guardians are at .239 (ranking 24th in the Major leagues), while the Red Sox are batting .246 (12th).

Home Runs

  • In terms of total home runs this season, the Red Sox have hit 162 (T22nd in the Major Leagues). Meanwhile, the Guardians have managed 152 (27th).

Runs Batted In

  • Finally, looking at their runs batted in, the Guardians have recorded 624 RBIs to rank T25th in the MLB this season. Comparatively, the Red Sox have recorded 650 RBIs to rank 20th.

Pitching Insights:

Earned Run Average

  • The Red Sox have an earned run average of 3.59 this season (3rd in the Majors), while The Guardians have an ERA of 3.77 (8th).

Strikeouts

  • Turning our attention to total strikeouts, the Guardians have recorded 1488 this season, ranking 3rd in the MLB. Meanwhile, the Red Sox rank 10th for total strikeouts, recording 1361.

Opponent Batting Average

  • Opponents are batting an average of .242 against the Red Sox this season (15th in the Major Leagues). Comparatively, the Guardians' opponents are at .236 (8th).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Guardians 36-27-94 21-14-46 15-13-48 25-18-57 11-9-37 0-0-0 3-1-6
    Red Sox 32-43-82 18-18-40 14-25-42 23-28-58 9-15-24 0-0-0 1-3-6

Lead After Three Innings

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Guardians 57-52-48 35-25-21 22-27-27 39-33-28 18-19-20 0-0-0 5-3-2
    Red Sox 65-60-32 36-28-12 29-32-20 49-38-22 16-22-10 0-0-0 4-5-1

NRFI/YRFI

  • The NRFI is 88-69 in Guardians games this season. The Red Sox have a 76-81 NRFI record.

Last Time They Met

The Guardians recorded a 3-2 victory over the Red Sox at Fenway Park yesterday. Despite being on the wrong side of that result, Adley Rutschman did what he could, hitting a home run.