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MLB Prop Bets: Boston Red Sox vs San Diego Padres (April 4, 2026)

The San Diego Padres (2-5) face the Boston Red Sox (2-5) at Fenway Park on Saturday at 4:10pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Randy Vasquez is the probable pitcher for the Padres, while Connelly Early is the probable pitcher for the Red Sox. The Red Sox are favored to win at -149, while the Padres are at +123. The total runs line is set at 8.0, with OVER at -110 and UNDER at -110.

  • The Padres (-181) have a 92-80 Run Line record since the beginning of last season, while the Red Sox (+149) hold a record of 87-85 across the same span.
  • The Padres have a 71-95-6 O/U record since the beginning of last season (meaning 71 games have gone over the total runs line, 95 have gone under and six have resulted in a push). The Red Sox have an 80-88-4 O/U record.

Scoring Insights

  • The Padres have scored 4.3 runs per game since the beginning of last season (20th in the league). Comparatively, the Red Sox have averaged 4.8 over the same span (8th).
  • In the field, the Padres have allowed just 3.9 runs per game since the beginning of last season (2nd in the league), while the Red Sox have allowed an average of 4.2 runs over that span (T12th).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages since the beginning of last season, the Padres are at .250 (ranking 10th in the Major leagues), while the Red Sox are batting .253 (5th).

Home Runs

  • In terms of total home runs since the beginning of last season, the Red Sox have hit 194 (15th in the Major Leagues). Meanwhile, the Padres have managed 155 (T28th).

Runs Batted In

  • Finally, looking at their runs batted in, the Padres have recorded 681 RBIs to rank T21st in the MLB since the beginning of last season. Comparatively, the Red Sox have recorded 769 RBIs to rank 9th.

Pitching Insights:

Earned Run Average

  • The Red Sox have an earned run average of 3.73 since the beginning of last season (5th in the Majors), while The Padres have an ERA of 3.65 (3rd).

Strikeouts

  • Turning our attention to total strikeouts, the Padres have recorded 1493 since the beginning of last season, ranking 8th in the MLB. Meanwhile, the Red Sox rank 17th for total strikeouts, recording 1421.

Opponent Batting Average

  • Opponents are batting an average of .243 against the Red Sox since the beginning of last season (16th in the Major Leagues). Comparatively, the Padres' opponents are at .226 (1st).

First Innings Moneyline

  • Here are their first innings moneyline records since the beginning of last season.
    Total Home Road Favorite Underdog Neutral
    Padres 36-42-94 20-20-47 16-22-47 23-26-48 13-16-46 0-0-0
    Red Sox 42-46-84 21-18-43 21-28-41 28-25-57 14-21-27 0-0-0

Lead After Three Innings

  • Here are their records after the first three innings since the beginning of last season.
    Total Home Road Favorite Underdog Neutral
    Padres 63-66-43 35-29-23 28-37-20 39-36-22 24-30-21 0-0-0
    Red Sox 66-62-44 38-23-21 28-39-23 49-33-28 17-29-16 0-0-0

NRFI/YRFI

The NRFI market is paying -125 and the YRFI is paying -105.

  • The NRFI is 89-83 in Padres games since the beginning of last season. The Red Sox have an 80-92 NRFI record.

Last Time They Met

The Red Sox recorded a 5-2 victory over the Padres at Fenway Park yesterday. Marcelo Mayer was unstoppable in that matchup, hitting a home run, a double and recording 2 RBIs.