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MLB Prop Bets: Athletics vs Houston Astros (April 5, 2026)

The Houston Astros (6-3) face the Athletics (2-6) at Sutter Health Park on Sunday at 4:05pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Lance McCullers Jr. is the probable pitcher for the Astros, while Jacob Lopez is the probable pitcher for the Athletics. The Astros are favored to win at -122, while the Athletics are at +102. The total runs line is set at 10.0, with OVER at -110 and UNDER at -110.

  • The Astros (+123) have an 86-85 Run Line record since the beginning of last season, while the Athletics (-149) hold a record of 92-78 across the same span.
  • The Astros have a 79-84-8 O/U record since the beginning of last season (meaning 79 games have gone over the total runs line, 84 have gone under and eight have resulted in a push). The Athletics have an 81-81-8 O/U record.

Scoring Insights

  • The Astros have scored 4.4 runs per game since the beginning of last season (16th in the league). Comparatively, the Athletics have averaged 4.5 over the same span (13th).
  • In the field, the Astros have allowed 4.1 runs per game since the beginning of last season (10th in the league), while the Athletics have allowed an average of 5.1 runs over that span (27th).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages since the beginning of last season, the Astros are at .252 (ranking 8th in the Major leagues), while the Athletics are batting .251 (9th).

Home Runs

  • In terms of total home runs since the beginning of last season, the Athletics have hit 227 (7th in the Major Leagues). Meanwhile, the Astros have managed 193 (16th).

Runs Batted In

  • Finally, looking at their runs batted in, the Astros have recorded 709 RBIs to rank 16th in the MLB since the beginning of last season. Comparatively, the Athletics have recorded 737 RBIs to rank 13th.

Pitching Insights:

Earned Run Average

  • The Athletics have an earned run average of 4.72 since the beginning of last season (27th in the Majors), while The Astros have an ERA of 3.91 (14th).

Strikeouts

  • Turning our attention to total strikeouts, the Astros have recorded 1607 since the beginning of last season, ranking 1st in the MLB. Meanwhile, the Athletics rank T21st for total strikeouts, recording 1375.

Opponent Batting Average

  • Opponents are batting an average of .253 against the Athletics since the beginning of last season (24th in the Major Leagues). Comparatively, the Astros' opponents are at .232 (6th).

First Innings Moneyline

  • Here are their first innings moneyline records since the beginning of last season.
    Total Home Road Favorite Underdog Neutral
    Astros 36-36-99 19-20-49 17-16-50 18-21-70 18-15-29 0-0-0
    Athletics 39-41-90 24-23-36 15-18-54 10-11-21 29-30-69 0-0-0

Lead After Three Innings

  • Here are their records after the first three innings since the beginning of last season.
    Total Home Road Favorite Underdog Neutral
    Astros 62-64-45 32-38-18 30-26-27 38-42-29 24-22-16 0-0-0
    Athletics 64-75-31 32-35-16 32-40-15 17-16-9 47-59-22 0-0-0

NRFI/YRFI

  • The NRFI is 93-78 in Astros games since the beginning of last season. The Athletics have an 84-86 NRFI record.

Last Time They Met

The Astros recorded a lopsided 11-0 victory against the Athletics at Sutter Health Park yesterday. Christian Walker was unstoppable in that matchup, hitting a home run, a double and recording 2 RBIs.