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MLB Prop Bets: Washington Nationals vs St. Louis Cardinals (April 6, 2026)

The St. Louis Cardinals (5-4) face the Washington Nationals (3-6) at Nationals Park on Monday at 6:45pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Andre Pallante is the probable pitcher for the Cardinals, while Zack Littell is the probable pitcher for the Nationals. The total runs line is set at 8.0, with OVER at -113 and UNDER at -107.

  • The Cardinals (+141) have an 84-87 Run Line record since the beginning of last season, while the Nationals (-171) hold a record of 83-88 across the same span.
  • The Cardinals have an 85-78-8 O/U record since the beginning of last season (meaning 85 games have gone over the total runs line, 78 have gone under and eight have resulted in a push). The Nationals have an 89-72-10 O/U record.

Scoring Insights

  • The Cardinals have scored 4.3 runs per game since the beginning of last season (20th in the league). Comparatively, the Nationals have averaged 4.3 over the same span (T17th).
  • In the field, the Cardinals have allowed 4.7 runs per game since the beginning of last season (21st in the league), while the Nationals have allowed an average of 5.6 runs over that span (29th).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages since the beginning of last season, the Cardinals are at .244 (ranking 19th in the Major leagues), while the Nationals are batting .244 (18th).

Home Runs

  • In terms of total home runs since the beginning of last season, the Nationals have hit 172 (24th in the Major Leagues). Meanwhile, the Cardinals have managed 156 (29th).

Runs Batted In

  • Finally, looking at their runs batted in, the Cardinals have recorded 692 RBIs to rank T21st in the MLB since the beginning of last season. Comparatively, the Nationals have recorded 708 RBIs to rank 17th.

Pitching Insights:

Earned Run Average

  • The Nationals have an earned run average of 5.40 since the beginning of last season (29th in the Majors), while The Cardinals have an ERA of 4.32 (21st).

Strikeouts

  • Turning our attention to total strikeouts, the Cardinals have recorded 1264 since the beginning of last season, ranking 29th in the MLB. Meanwhile, the Nationals rank 28th for total strikeouts, recording 1315.

Opponent Batting Average

  • Opponents are batting an average of .269 against the Nationals since the beginning of last season (29th in the Major Leagues). Comparatively, the Cardinals' opponents are at .260 (28th).

First Innings Moneyline

  • Here are their first innings moneyline records since the beginning of last season.
    Total Home Road Favorite Underdog Neutral
    Cardinals 31-52-88 13-28-46 18-24-42 10-22-32 21-30-56 0-0-0
    Nationals 37-48-86 16-25-43 21-23-43 3-5-13 34-43-73 0-0-0

Lead After Three Innings

  • Here are their records after the first three innings since the beginning of last season.
    Total Home Road Favorite Underdog Neutral
    Cardinals 58-64-49 32-28-27 26-36-22 26-25-13 32-39-36 0-0-0
    Nationals 56-77-38 28-36-20 28-41-18 5-6-10 51-71-28 0-0-0

NRFI/YRFI

The NRFI market is paying -130 and the YRFI is paying +100.

  • The NRFI is 86-85 in Cardinals games since the beginning of last season. The Nationals have an 82-89 NRFI record.

Last Time They Met

The Cardinals recorded an 8-1 victory over the Nationals at Busch Stadium when these teams last met on July 10, 2025. Willson Contreras was unstoppable in that matchup, hitting a home run, a single and recording an RBI.