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MLB Prop Bets: Pittsburgh Pirates vs St. Louis Cardinals (April 28, 2026)

The St. Louis Cardinals (15-13) face the Pittsburgh Pirates (16-13) at PNC Park on Tuesday at 6:40pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Kyle Leahy is the probable pitcher for the Cardinals, while the Pirates' probable pitcher remains unclear. The Pirates are favored to win at -163, while the Cardinals are at +135. The total runs line is set at 8.0, with OVER at -115 and UNDER at -105.

  • The Cardinals (-163) have a 17-11 Run Line record this season, while the Pirates (+135) hold a record of 17-12.
  • The Cardinals have a 14-14-0 O/U record this season (meaning 14 games have gone over the total runs line and 14 have gone under). The Pirates have a 14-15-0 O/U record.

Scoring Insights

  • The Cardinals are averaging 4.6 runs per game this season (14th in the league). Comparatively, the Pirates are averaging 4.7 (12th).
  • In the field, the Cardinals are allowing 5.1 runs per game this season (24th in the league), while the Pirates are allowing an average of 4.0 runs (5th).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the Cardinals are at .234 (ranking 22nd in the Major leagues), while the Pirates are batting .241 (13th).

Home Runs

  • In terms of total home runs this season, the Pirates have hit 29 (T18th in the Major Leagues). Meanwhile, the Cardinals have managed 36 (8th).

Runs Batted In

  • Finally, looking at their runs batted in, the Cardinals have recorded 126 RBIs to rank T14th in the MLB this season. Comparatively, the Pirates have recorded 132 RBIs to rank 9th.

Pitching Insights:

Earned Run Average

  • The Pirates have one of the strongest earned run averages this season, sitting at 3.36 (4th in the Majors), while the Cardinals are at the opposite end of the scale with an ERA of 4.77 (27th).

Strikeouts

  • Turning our attention to total strikeouts, the Pirates have recorded an impressive 268 this season, ranking 3rd in the MLB. Contrastingly, the Cardinals rank 30th for total strikeouts, recording only 189.

Opponent Batting Average

  • Opponents are batting an average of only .218 against the Pirates this season (3rd in the Major Leagues). Alternatively, the Cardinals' opponents are at .260 (25th).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Cardinals 4-5-19 1-2-12 3-3-7 0-2-1 4-3-18 0-0-0 2-1-7
    Pirates 10-3-16 5-2-7 5-1-9 6-2-6 4-1-10 0-0-0 5-0-5

Lead After Three Innings

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Cardinals 10-9-9 6-3-6 4-6-3 1-1-1 9-8-8 0-0-0 5-4-1
    Pirates 14-5-10 8-1-5 6-4-5 9-2-3 5-3-7 0-0-0 5-3-2

NRFI/YRFI

The NRFI market is paying -115 and the YRFI is paying -110.

  • The NRFI is 14-14 in Cardinals games this season. The Pirates have a 16-13 NRFI record.

Last Time They Met

The Cardinals recorded a 4-2 victory over the Pirates at PNC Park yesterday. Pedro Pages went yard en route to that victory, hitting a home run to go with an RBI. That result snapped the Pirates' four-game winning streak against the Cardinals at PNC Park.