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MLB Prop Bets: San Diego Padres vs Chicago Cubs (April 28, 2026)

The Chicago Cubs (17-12) face the San Diego Padres (19-9) at Petco Park on Tuesday at 9:40pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Edward Cabrera is the probable pitcher for the Cubs, while Walker Buehler is the probable pitcher for the Padres. The total runs line is set at 8.5, with OVER at -104 and UNDER at -116.

  • The Cubs (+135) have a 14-15 Run Line record this season, while the Padres (-163) hold a record of 16-12.
  • The Cubs have an 18-10-1 O/U record this season (meaning 18 games have gone over the total runs line, 10 have gone under and one has resulted in a push). The Padres have a 12-15-1 O/U record.

Scoring Insights

  • The Cubs are averaging 5.4 runs per game this season (T3rd in the league). Comparatively, the Padres are averaging only 4.7 (13th).
  • In the field, the Cubs are allowing 4.4 runs per game this season (14th in the league), while the Padres are allowing an average of 4.2 runs (11th).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the Cubs are at .262 (ranking 3rd in the Major leagues), while the Padres are batting .240 (15th).

Home Runs

  • In terms of total home runs this season, the Padres have hit 26 (24th in the Major Leagues). Meanwhile, the Cubs have managed 39 (T4th).

Runs Batted In

  • Finally, looking at their runs batted in, the Cubs have recorded 141 RBIs to rank 6th in the MLB this season. Comparatively, the Padres have recorded 127 RBIs to rank T11th.

Pitching Insights:

Earned Run Average

  • The Padres have an earned run average of 4.07 this season (14th in the Majors), while The Cubs have an ERA of 4.05 (13th).

Strikeouts

  • Turning our attention to total strikeouts, the Cubs have recorded 233 this season, ranking 21st in the MLB. Meanwhile, the Padres rank T11th for total strikeouts, recording 250.

Opponent Batting Average

  • Opponents are batting an average of .245 against the Padres this season (18th in the Major Leagues). Comparatively, the Cubs' opponents are at .234 (10th).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Cubs 4-6-19 3-2-11 1-4-8 3-2-13 1-4-6 0-0-0 1-2-7
    Padres 4-4-20 3-3-8 1-1-10 4-2-11 0-2-9 0-0-2 2-1-7

Lead After Three Innings

The Cubs are -120 to lead after three innings, while the Padres are -110.

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Cubs 13-8-8 8-3-5 5-5-3 9-3-6 4-5-2 0-0-0 4-2-4
    Padres 7-12-9 5-6-3 1-5-6 4-6-7 3-6-2 1-1-0 2-5-3

NRFI/YRFI

The NRFI market is paying -120 and the YRFI is paying -110.

  • The NRFI is 19-10 in Cubs games this season. The Padres have a 20-8 NRFI record.

Last Time They Met

The Padres recorded a 9-7 victory over the Cubs at Petco Park yesterday. Ty France went yard en route to that victory, hitting a home run to go with 4 RBIs.