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MLB Prop Bets: Chicago Cubs vs Arizona Diamondbacks (May 1, 2026)

The Arizona Diamondbacks (16-14) face the Chicago Cubs (19-12) at Wrigley Field on Friday at 2:20pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Zac Gallen is the probable pitcher for the Diamondbacks, while Colin Rea is the probable pitcher for the Cubs. The Cubs are favored to win at -136, while the Diamondbacks are at +113.

  • The Diamondbacks have a 17-11-2 O/U record this season (meaning 17 games have gone over the total runs line, 11 have gone under and two have resulted in a push). The Cubs have a 20-10-1 O/U record.

Scoring Insights

  • The Diamondbacks are averaging 4.7 runs per game this season (11th in the league). Comparatively, the Cubs are averaging 5.5 (3rd).
  • In the field, the Diamondbacks are allowing a whopping 5.5 runs per game this season (28th in the league), while the Cubs are allowing an average of 4.3 runs (T10th).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the Diamondbacks are at .250 (ranking 9th in the Major leagues), while the Cubs are batting .261 (4th).

Home Runs

  • In terms of total home runs this season, the Cubs have hit 42 (T4th in the Major Leagues). Meanwhile, the Diamondbacks have managed 31 (T18th).

Runs Batted In

  • Finally, looking at their runs batted in, the Diamondbacks have recorded 135 RBIs to rank T13th in the MLB this season. Comparatively, the Cubs have recorded 154 RBIs to rank 6th.

Pitching Insights:

Earned Run Average

  • The Cubs have an earned run average of 4.01 this season (12th in the Majors), while The Diamondbacks have an ERA of 4.99 (28th).

Strikeouts

  • Turning our attention to total strikeouts, the Diamondbacks have recorded 222 this season, ranking 29th in the MLB. Meanwhile, the Cubs rank 20th for total strikeouts, recording 251.

Opponent Batting Average

  • Opponents are batting an average of .229 against the Cubs this season (8th in the Major Leagues). Comparatively, the Diamondbacks' opponents are at .259 (23rd).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Diamondbacks 7-9-14 3-4-6 4-5-6 2-2-4 5-7-10 0-0-2 1-5-4
    Cubs 4-6-21 3-2-11 1-4-10 3-2-14 1-4-7 0-0-0 1-2-7

Lead After Three Innings

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Diamondbacks 9-14-7 4-4-5 4-9-2 4-1-3 5-13-4 1-1-0 2-6-2
    Cubs 15-8-8 8-3-5 7-5-3 10-3-6 5-5-2 0-0-0 6-2-2

NRFI/YRFI

  • The NRFI is 12-18 in Diamondbacks games this season. The Cubs have a 21-10 NRFI record.

Last Time They Met

The Diamondbacks recorded a 3-2 extra innings victory over the Cubs at Wrigley Field when these teams last met on April 20, 2025. Josh Naylor went yard en route to that victory, hitting a home run to go with 2 RBIs. That result snapped the Cubs' three-game winning streak against the Diamondbacks at Wrigley Field.