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MLB Prop Bets: San Diego Padres vs Chicago White Sox (May 1, 2026)

The Chicago White Sox (14-17) face the San Diego Padres (19-11) at Petco Park on Friday at 9:40pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Noah Schultz is the probable pitcher for the White Sox, while German Marquez is the probable pitcher for the Padres. The Padres are favored to win at -156, while the White Sox are at +129. The total runs line is set at 8.0, with OVER at -112 and UNDER at -108.

  • The White Sox (-171) have a 14-17 Run Line record this season, while the Padres (+141) hold a record of 16-14.
  • The White Sox have an 18-13-0 O/U record this season (meaning 18 games have gone over the total runs line and 13 have gone under). The Padres have a 14-15-1 O/U record.

Scoring Insights

  • The White Sox are averaging 4.2 runs per game this season (22nd in the league). Comparatively, the Padres are averaging 4.6 (14th).
  • In the field, the White Sox are allowing 4.9 runs per game this season (23rd in the league), while the Padres are allowing an average of 4.4 runs (12th).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the White Sox are at .225 (ranking 29th in the Major leagues), while the Padres are batting .235 (21st).

Home Runs

  • In terms of total home runs this season, the Padres have hit 29 (T22nd in the Major Leagues). Meanwhile, the White Sox have managed 38 (T9th).

Runs Batted In

  • Finally, looking at their runs batted in, the White Sox have recorded 119 RBIs to rank T22nd in the MLB this season. Comparatively, the Padres have recorded 134 RBIs to rank 15th.

Pitching Insights:

Earned Run Average

  • The Padres have an earned run average of 4.23 this season (18th in the Majors), while The White Sox have an ERA of 4.49 (23rd).

Strikeouts

  • Turning our attention to total strikeouts, the White Sox have recorded 246 this season, ranking T26th in the MLB. Meanwhile, the Padres rank 16th for total strikeouts, recording 260.

Opponent Batting Average

  • Opponents are batting an average of .244 against the Padres this season (16th in the Major Leagues). Comparatively, the White Sox's opponents are at .245 (17th).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    White Sox 9-6-16 3-2-10 6-4-6 0-1-3 9-5-13 0-0-0 3-2-5
    Padres 4-4-22 3-3-10 1-1-10 4-2-12 0-2-10 0-0-2 2-1-7

Lead After Three Innings

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    White Sox 14-10-7 7-4-4 7-6-3 0-2-2 14-8-5 0-0-0 4-3-3
    Padres 7-14-9 5-8-3 1-5-6 4-7-7 3-7-2 1-1-0 1-6-3

NRFI/YRFI

  • The NRFI is 16-15 in White Sox games this season. The Padres have a 22-8 NRFI record.

Last Time They Met

The Padres recorded an upset 3-2 victory over the White Sox at Rate Field when these teams last met on September 21, 2025. Fernando Tatis Jr. was unstoppable in that matchup, hitting a home run, a single and recording an RBI.