MLB Prop Bets: San Diego Padres vs St. Louis Cardinals (May 7, 2026)
The St. Louis Cardinals (21-15) face the San Diego Padres (22-14) at Petco Park on Thursday at 10:10pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Matthew Liberatore is the probable pitcher for the Cardinals, while Michael King is the probable pitcher for the Padres. The Padres are favored to win at -175, while the Cardinals are at +144. The total runs line is set at 8.0, with OVER at -110 and UNDER at -110.
- The Cardinals (-149) have a 23-13 Run Line record this season, while the Padres (+123) hold a record of 18-18.
- The Cardinals have a 19-16-1 O/U record this season (meaning 19 games have gone over the total runs line, 16 have gone under and one has resulted in a push). The Padres have a 16-19-1 O/U record.
Scoring Insights
- The Cardinals are averaging 4.8 runs per game this season (9th in the league). Comparatively, the Padres are averaging 4.5 (13th).
- In the field, the Cardinals are allowing 4.9 runs per game this season (24th in the league), while the Padres are allowing an average of 4.3 runs (14th).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the Cardinals are at .240 (ranking 16th in the Major leagues), while the Padres are batting .233 (22nd).
Home Runs
- In terms of total home runs this season, the Padres have hit 36 (T20th in the Major Leagues). Meanwhile, the Cardinals have managed 44 (9th).
Runs Batted In
- Finally, looking at their runs batted in, the Cardinals have recorded 170 RBIs to rank T9th in the MLB this season. Comparatively, the Padres have recorded 155 RBIs to rank 14th.
Pitching Insights:
Earned Run Average
- The Padres have an earned run average of 4.21 this season (16th in the Majors), while The Cardinals have an ERA of 4.54 (23rd).
Strikeouts
- Turning our attention to total strikeouts, the Cardinals have recorded 249 this season, ranking 30th in the MLB. Meanwhile, the Padres rank 14th for total strikeouts, recording 314.
Opponent Batting Average
- Opponents are batting an average of .239 against the Padres this season (14th in the Major Leagues). Comparatively, the Cardinals' opponents are at .263 (26th).
First Innings Moneyline
- Here are their first innings moneyline records in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Cardinals | 6-6-24 | 2-3-15 | 4-3-9 | 0-2-1 | 6-4-23 | 0-0-0 | 2-2-6 |
| Padres | 4-6-26 | 3-3-13 | 1-3-11 | 4-3-15 | 0-3-11 | 0-0-2 | 1-2-7 |
Lead After Three Innings
The Cardinals are +124 to lead after three innings, while the Padres are -160.
- Here are their records after the first three innings in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Cardinals | 16-11-9 | 9-5-6 | 7-6-3 | 1-1-1 | 15-10-8 | 0-0-0 | 7-3-0 |
| Padres | 7-18-11 | 5-10-4 | 1-7-7 | 4-10-8 | 3-8-3 | 1-1-0 | 1-7-2 |
NRFI/YRFI
The NRFI market is paying -135 and the YRFI is paying +105.
- The NRFI is 19-17 in Cardinals games this season. The Padres have a 26-10 NRFI record.
Last Time They Met
The Padres recorded an upset 7-3 victory over the Cardinals at Petco Park when these teams last met on August 3, 2025. Ramon Laureano was unstoppable in that matchup, hitting a home run, a single and recording an RBI.
