MLB Prop Bets: Detroit Tigers vs Cleveland Guardians (May 21, 2026)
The Cleveland Guardians (29-22) face the Detroit Tigers (20-30) at Comerica Park on Thursday at 1:10pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Joey Cantillo is the probable pitcher for the Guardians, while Casey Mize is the probable pitcher for the Tigers. The Tigers are favored to win at -114, while the Guardians are at -105. The total runs line is set at 7.5, with OVER at +101 and UNDER at -122.
- The Guardians (+157) have a 26-25 Run Line record this season, while the Tigers (-191) hold a record of 23-27.
- The Guardians have a 26-25-0 O/U record this season (meaning 26 games have gone over the total runs line and 25 have gone under). The Tigers have a 22-27-1 O/U record.
Scoring Insights
- The Guardians are averaging 4.4 runs per game this season (15th in the league). Comparatively, the Tigers are averaging only 3.9 (27th).
- In the field, the Guardians are allowing 4.0 runs per game this season (T8th in the league), while the Tigers are allowing an average of 4.3 runs (11th).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the Guardians are at .231 (ranking 26th in the Major leagues), while the Tigers are batting .236 (18th).
Home Runs
- In terms of total home runs this season, the Tigers have hit 43 (25th in the Major Leagues). Meanwhile, the Guardians have managed 52 (16th).
Runs Batted In
- Finally, looking at their runs batted in, the Guardians have recorded 215 RBIs to rank 11th in the MLB this season. Comparatively, the Tigers have recorded 184 RBIs to rank 27th.
Pitching Insights:
Earned Run Average
- The Tigers have an earned run average of 3.98 this season (13th in the Majors), while The Guardians have an ERA of 3.72 (9th).
Strikeouts
- Turning our attention to total strikeouts, the Guardians have recorded 471 this season, ranking 2nd in the MLB. Meanwhile, the Tigers rank 18th for total strikeouts, recording 403.
Opponent Batting Average
- Opponents are batting an average of .238 against the Tigers this season (14th in the Major Leagues). Comparatively, the Guardians' opponents are at .235 (12th).
First Innings Moneyline
- Here are their first innings moneyline records in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Guardians | 11-8-32 | 6-3-16 | 5-5-16 | 6-5-18 | 5-3-14 | 0-0-0 | 2-1-7 |
| Tigers | 11-9-30 | 6-3-15 | 5-6-15 | 9-6-14 | 2-3-16 | 0-0-0 | 3-1-6 |
Lead After Three Innings
- Here are their records after the first three innings in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Guardians | 21-16-14 | 12-6-7 | 9-10-7 | 12-7-10 | 9-9-4 | 0-0-0 | 6-2-2 |
| Tigers | 19-19-12 | 10-9-5 | 9-10-7 | 14-10-5 | 5-9-7 | 0-0-0 | 4-3-3 |
NRFI/YRFI
The NRFI market is paying -145 and the YRFI is paying +110.
- The NRFI is 29-22 in Guardians games this season. The Tigers have a 29-21 NRFI record.
Last Time They Met
The Guardians recorded a 3-2 extra innings victory over the Tigers at Comerica Park yesterday. Chase DeLauter led the way to that victory, hitting a home run. The Guardians have now won six straight at Comerica Park against the Tigers.
