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MLB Prop Bets: Arizona Diamondbacks vs Cincinnati Reds (August 21, 2026)

The Cincinnati Reds (61-67) face the Arizona Diamondbacks (67-61) at Chase Field on Friday at 9:40pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Nick Lodolo is the probable pitcher for the Reds, while Eduardo Rodriguez is the probable pitcher for the Diamondbacks. The Diamondbacks are favored to win at -156, while the Reds are at +129. The total runs line is set at 8.5, with OVER at -102 and UNDER at -118.

  • The Reds (-175) have a 66-62 Run Line record this season, while the Diamondbacks (+144) hold a record of 71-57.
  • The Reds have a 67-60-1 O/U record this season (meaning 67 games have gone over the total runs line, 60 have gone under and one has resulted in a push). The Diamondbacks have a 53-66-9 O/U record.

Scoring Insights

  • The Reds are averaging 4.1 runs per game this season (25th in the league). Comparatively, the Diamondbacks are averaging +0.4 more at 4.5 runs (14th).
  • In the field, the Reds are allowing 4.8 runs per game this season (24th in the league), while the Diamondbacks are allowing an average of 4.5 runs (19th).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the Reds are at .226 (ranking 30th in the Major leagues), while the Diamondbacks are batting .243 (16th).

Home Runs

  • In terms of total home runs this season, the Diamondbacks have hit 126 (27th in the Major Leagues). Meanwhile, the Reds have managed 165 (7th).

Runs Batted In

  • Finally, looking at their runs batted in, the Reds have recorded 499 RBIs to rank 25th in the MLB this season. Comparatively, the Diamondbacks have recorded 551 RBIs to rank T14th.

Pitching Insights:

Earned Run Average

  • The Diamondbacks have an earned run average of 4.18 this season (18th in the Majors), while The Reds have an ERA of 4.47 (24th).

Strikeouts

  • Turning our attention to total strikeouts, the Reds have recorded 1039 this season, ranking 21st in the MLB. Meanwhile, the Diamondbacks rank T29th for total strikeouts, recording 865.

Opponent Batting Average

  • Opponents are batting an average of .252 against the Diamondbacks this season (25th in the Major Leagues). Comparatively, the Reds' opponents are at .246 (18th).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Reds 27-34-67 13-16-39 14-18-28 11-9-21 16-25-46 0-0-0 2-2-6
    Diamondbacks 29-35-64 17-13-31 12-22-31 16-10-25 13-25-39 0-0-2 5-3-2

Lead After Three Innings

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Reds 38-50-40 21-23-24 17-27-16 15-13-13 23-37-27 0-0-0 2-3-5
    Diamondbacks 41-60-27 26-20-15 14-39-12 23-15-13 18-45-14 1-1-0 5-5-0

NRFI/YRFI

The NRFI market is paying -115 and the YRFI is paying -110.

  • The NRFI is 64-64 in Reds games this season. The Diamondbacks have a 56-72 NRFI record.

Last Time They Met

The Diamondbacks recorded a 5-3 victory over the Reds at Great American Ball Park when these teams last met on June 14. Geraldo Perdomo was unstoppable in that matchup, hitting a home run, a single and recording 2 RBIs.