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MLB Prop Bets: Boston Red Sox vs San Francisco Giants (August 21, 2026)

The San Francisco Giants (52-75) face the Boston Red Sox (68-59) at Fenway Park on Friday at 7:10pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Logan Webb is the probable pitcher for the Giants, while Sonny Gray is the probable pitcher for the Red Sox. The Red Sox are favored to win at -186, while the Giants are at +153. The total runs line is set at 7.5, with OVER at -105 and UNDER at -114.

  • The Giants (-143) have a 63-64 Run Line record this season, while the Red Sox (+119) hold a record of 62-65.
  • The Giants have a 57-58-12 O/U record this season (meaning 57 games have gone over the total runs line, 58 have gone under and 12 have resulted in a push). The Red Sox have a 59-64-4 O/U record.

Scoring Insights

  • The Giants are averaging 4.0 runs per game this season (26th in the league). Comparatively, the Red Sox are averaging +0.5 more at 4.5 runs (13th).
  • In the field, the Giants are allowing 4.6 runs per game this season (20th in the league), while the Red Sox are allowing an average of 3.8 runs (3rd).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the Giants are at .247 (ranking 10th in the Major leagues), while the Red Sox are batting .250 (6th).

Home Runs

  • In terms of total home runs this season, the Red Sox have hit 131 (T23rd in the Major Leagues). Meanwhile, the Giants have managed 139 (20th).

Runs Batted In

  • Finally, looking at their runs batted in, the Giants have recorded 493 RBIs to rank 27th in the MLB this season. Comparatively, the Red Sox have recorded 550 RBIs to rank T16th.

Pitching Insights:

Earned Run Average

  • The Red Sox have an earned run average of 3.52 this season (3rd in the Majors), while The Giants have an ERA of 4.35 (23rd).

Strikeouts

  • Turning our attention to total strikeouts, the Giants have recorded 959 this season, ranking 27th in the MLB. Meanwhile, the Red Sox rank 13th for total strikeouts, recording 1083.

Opponent Batting Average

  • Opponents are batting an average of .239 against the Red Sox this season (12th in the Major Leagues). Comparatively, the Giants' opponents are at .247 (19th).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Giants 26-32-69 14-9-39 12-23-30 9-6-28 17-26-41 0-0-0 2-3-5
    Red Sox 29-36-62 18-15-30 11-21-32 21-22-43 8-14-19 0-0-0 3-1-6

Lead After Three Innings

The Giants are +130 to lead after three innings, while the Red Sox are -166.

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Giants 41-52-34 20-23-19 21-29-15 14-15-14 27-37-20 0-0-0 2-3-5
    Red Sox 54-45-28 32-20-11 22-25-17 41-27-18 13-18-10 0-0-0 5-3-2

NRFI/YRFI

The NRFI market is paying -160 and the YRFI is paying +120.

  • The NRFI is 68-59 in Giants games this season. The Red Sox have a 60-67 NRFI record.

Last Time They Met

The Giants recorded a 9-5 victory over the Red Sox at Oracle Park when these teams last met on June 22, 2025. Casey Schmitt dominated at the plate in that matchup, notching 1 home run, 2 singles and an RBI.