MLB Prop Bets: St. Louis Cardinals vs San Francisco Giants (September 16, 2026)
The San Francisco Giants (63-89) face the St. Louis Cardinals (75-77) at Busch Stadium on Wednesday at 1:15pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Anthony Molina is the probable pitcher for the Giants, while Matthew Liberatore is the probable pitcher for the Cardinals. The Cardinals are favored to win at -163, while the Giants are at +135. The total runs line is set at 8.0, with OVER at -108 and UNDER at -112.
- The Giants (-163) have a 78-74 Run Line record this season, while the Cardinals (+135) hold a record of 83-69.
- The Giants have a 72-67-13 O/U record this season (meaning 72 games have gone over the total runs line, 67 have gone under and 13 have resulted in a push). The Cardinals have a 70-76-6 O/U record.
Scoring Insights
- The Giants are averaging 4.2 runs per game this season (23rd in the league). Comparatively, the Cardinals are averaging +0.3 more at 4.5 runs (12th).
- In the field, the Giants are allowing 4.7 runs per game this season (23rd in the league), while the Cardinals are allowing an average of 4.6 runs (20th).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the Giants are at .247 (ranking 12th in the Major leagues), while the Cardinals are batting .243 (18th).
Home Runs
- In terms of total home runs this season, the Cardinals have hit 158 (22nd in the Major Leagues). Meanwhile, the Giants have managed 174 (15th).
Runs Batted In
- Finally, looking at their runs batted in, the Giants have recorded 622 RBIs to rank 22nd in the MLB this season. Comparatively, the Cardinals have recorded 668 RBIs to rank 9th.
Pitching Insights:
Earned Run Average
- The Cardinals have an earned run average of 4.29 this season (21st in the Majors), while The Giants have an ERA of 4.37 (23rd).
Strikeouts
- Turning our attention to total strikeouts, the Giants have recorded 1132 this season, ranking 27th in the MLB. Meanwhile, the Cardinals rank 23rd for total strikeouts, recording 1211.
Opponent Batting Average
- Opponents are batting an average of .254 against the Cardinals this season (25th in the Major Leagues). Comparatively, the Giants' opponents are at .248 (19th).
First Innings Moneyline
- Here are their first innings moneyline records in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Giants | 40-36-76 | 23-10-42 | 17-26-34 | 11-6-29 | 29-30-47 | 0-0-0 | 7-1-2 |
| Cardinals | 32-31-89 | 12-13-52 | 20-18-37 | 12-14-26 | 20-17-63 | 0-0-0 | 0-5-5 |
Lead After Three Innings
- Here are their records after the first three innings in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Giants | 51-61-40 | 25-27-23 | 26-34-17 | 16-15-15 | 35-46-25 | 0-0-0 | 4-3-3 |
| Cardinals | 65-47-40 | 33-22-22 | 32-25-18 | 26-14-12 | 39-33-28 | 0-0-0 | 4-5-1 |
NRFI/YRFI
The NRFI market is paying -105 and the YRFI is paying -120.
- The NRFI is 73-79 in Giants games this season. The Cardinals have a 79-73 NRFI record.
Last Time They Met
The Giants recorded an upset 10-3 victory over the Cardinals at Busch Stadium yesterday. Bryce Eldridge was unstoppable in that matchup, hitting a home run, a double and recording 3 RBIs. That result snapped the Cardinals' three-game winning streak against the Giants at Busch Stadium.
