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MLB Prop Bets: Seattle Mariners vs Houston Astros (September 23, 2026)

The Houston Astros (78-79) face the Seattle Mariners (73-84) at T-Mobile Park on Wednesday at 10:10pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Ethan Pecko is the probable pitcher for the Astros, while George Kirby is the probable pitcher for the Mariners.

  • The Astros have a 75-71-11 O/U record this season (meaning 75 games have gone over the total runs line, 71 have gone under and 11 have resulted in a push). The Mariners have an 80-67-10 O/U record.

Scoring Insights

  • The Astros are averaging 4.4 runs per game this season (18th in the league). Comparatively, the Mariners are averaging only 4.0 (28th).
  • In the field, the Astros are allowing 4.8 runs per game this season (24th in the league), while the Mariners are allowing an average of 4.4 runs (T15th).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the Astros are at .240 (ranking 22nd in the Major leagues), while the Mariners are batting .231 (29th).

Home Runs

  • In terms of total home runs this season, the Mariners have hit 179 (T15th in the Major Leagues). Meanwhile, the Astros have managed 212 (3rd).

Runs Batted In

  • Finally, looking at their runs batted in, the Astros have recorded 664 RBIs to rank 19th in the MLB this season. Comparatively, the Mariners have recorded 611 RBIs to rank 28th.

Pitching Insights:

Earned Run Average

  • The Mariners have an earned run average of 4.21 this season (19th in the Majors), while The Astros have an ERA of 4.50 (24th).

Strikeouts

  • Turning our attention to total strikeouts, the Astros have recorded 1368 this season, ranking 9th in the MLB. Meanwhile, the Mariners rank 13th for total strikeouts, recording 1336.

Opponent Batting Average

  • Opponents are batting an average of .251 against the Mariners this season (23rd in the Major Leagues). Comparatively, the Astros' opponents are at .237 (11th).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Astros 43-37-77 25-14-42 18-23-35 20-14-35 23-23-42 0-0-0 4-1-5
    Mariners 38-42-77 21-18-37 17-24-40 31-29-59 7-13-18 0-0-0 4-4-2

Lead After Three Innings

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Astros 58-59-40 35-27-19 23-32-21 27-27-15 31-32-25 0-0-0 5-1-4
    Mariners 61-59-37 32-26-18 29-33-19 44-42-33 17-17-4 0-0-0 3-3-4

NRFI/YRFI

  • The NRFI is 72-85 in Astros games this season. The Mariners have a 70-87 NRFI record.

Last Time They Met

The Astros recorded a 7-0 victory over the Mariners at T-Mobile Park yesterday. Yordan Alvarez was unstoppable in that matchup, hitting a home run, a single and recording 3 RBIs. That result snapped the Mariners' four-game winning streak against the Astros at T-Mobile Park.