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NFL Prop Bets: San Francisco 49ers vs Los Angeles Rams - Week 10

The Los Angeles Rams (6-2) face the San Francisco 49ers (6-3) at Levi's Stadium for Week 10. Let's take a look at the NFL Prop Bets for Sunday's matchup. The Rams started the week as 3.5-point favorites but the spread has since moved to 6.0, leaving the Rams at -250 and 49ers at +200.

The total points line is set at 49.5, with OVER at -110 and UNDER at -110, meaning the implied expected score for the game is 28-22 LA Rams.

  • The Rams (-115) have a 6-2-0 ATS record this season, while the 49ers (-106) hold a record of 5-4-0.

Points on the board

  • The Rams are averaging 26.1 points per game this season (8th in the league). Comparatively, the 49ers are averaging only 21.6 (23rd).
  • Defensively, the Rams are giving up 15.9 points per game this season (2nd in the league), while the 49ers are giving up an average of 20.9 points (10th).

Moving the chains

  • With an average of 369.9, the Rams rank 7th in the league for total yards per game. Comparatively, the 49ers rank 10th with 352.1 yards per game.
  • In terms of yards allowed, the Rams are giving up 302.9 per game this season (10th in the league), while the 49ers are giving up an average of 332.6 (17th).

Ascendency in the air

  • The Rams have recorded 258.0 passing yards per game this season (1st in the league). Comparatively, the 49ers' defense has given up 223.7 passing yards per game (20th).
  • Meanwhile, the 49ers have recorded 255.0 passing yards per game this season (5th in the league), while the Rams' defense has given up 203.1 passing yards per game (13th).

Advantage on the ground

  • Looking at the ground game, the Rams have recorded 111.9 rushing yards per game this season (18th in the league). Although not a hugely inferior ranking, they remain below the 49ers' position of 15th for opponent rushing yards (conceding 108.9 per game).
  • On the other hand, the 49ers have recorded 97.1 rushing yards per game this season (26th in the league), while the Rams are giving up 99.8 rushing yards per game (11th).

Protecting the ball

  • Looking at their ability to force turnovers, the Rams have recorded 12 total takeaways this season (T6th in the league), while the 49ers have failed to perform at the same level, recording 7 (T23rd).
  • On offense, the Rams have recorded 7 total giveaways this season (T8th in the league), bettering the 49ers' number of 13 (T24th).

First to Score

  • The Rams have scored first in four of their eight games this season.
  • The 49ers have also scored first in four of their nine games.

Which team will score the first touchdown?

  • The Rams have recorded the first touchdown in five of their eight games this season.
  • The 49ers have also recorded the first touchdown in five of their nine games.

First Scoring Play

    Play Frequency Odds
    LA Rams Touchdown3 / 8
    LA Rams Field Goal1 / 8
    LA Rams Safety0 / 8
    San Francisco Touchdown3 / 9
    San Francisco Field Goal1 / 9
    San Francisco Safety0 / 9

Which team will get a quick start?

  • The Rams have been the first to score 10 points in six of their eight games this season.
  • The 49ers have also been the first to score 10 points in six of their nine games.

First Quarter Moneyline

  • The Rams have a 4-3-1 first quarter W/L/T record this season, while the 49ers hold a record of 4-2-3.

Last Time They Met

The 49ers recorded a 26-23 overtime victory over the Rams at SoFi Stadium when these teams last met in Week 5, 2025. That result snapped the Rams' three-game winning streak against the 49ers.