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NFL Prop Bets: Los Angeles Chargers vs Arizona Cardinals - Week 1

The Arizona Cardinals (0-0) face the Los Angeles Chargers (0-0) at SoFi Stadium for Week 1. Let's take a look at the NFL Prop Bets for Sunday's matchup. The Chargers started the week as 10.5-point favorites but the spread has since moved to 8.5, leaving the Chargers at -455 and Cardinals at +350.

The total points line is set at 47.5, with OVER at -102 and UNDER at -118, meaning the implied expected score for the game is 28-20 LA Chargers.

  • The Cardinals (-102) had a 6-11-0 ATS record last season, while the Chargers (-118) held a record of 9-9-0.
  • The Cardinals had a 10-7-0 O/U record last season (meaning 10 games went over the total points line and seven went under). The Chargers had a 6-11-1 O/U record last season.

Points on the board

  • The Cardinals scored 20.9 points per game last season (23rd in the league). Comparatively, the Chargers averaged 21.6 (20th).
  • Defensively, the Cardinals conceded a whopping 28.7 points per game last season (29th in the league), while the Chargers gave up an average of 20.0 points (9th).

Moving the chains

  • With an average of 325.8, the Cardinals ranked 19th in the league for total yards per game last season. Comparatively, the Chargers ranked 12th with 333.8 yards per game.
  • In terms of yards allowed, the Cardinals gave up 357.7 per game last season (27th in the league), an inferior number to the Chargers, who allowed an average of 285.2 (5th).

Ascendency in the air

  • The Cardinals averaged 232.6 passing yards per game last season (7th in the league). Comparatively, the Chargers' defense gave up 179.9 passing yards per game (5th) last season.
  • Meanwhile, the Chargers recorded 212.2 passing yards per game last season (18th in the league), while the Cardinals' defense conceded 230.8 yards per game (24th) in 2025, although it remains to be seen whether their slightly worse rating will have an impact on this matchup.

Advantage on the ground

  • Looking at the ground game, the Cardinals averaged 93.1 rushing yards per game last season (31st in the league). Conversely, the Chargers gave up 105.4 rushing yards per game (8th).
  • On the other hand, the Chargers averaged 121.6 rushing yards per game last season (12th in the league) and they may look to take the ascendancy in this part of the game given the Cardinals allowed 126.9 rushing yards per game (25th).

Protecting the ball

  • Looking at their ability to force turnovers, the Cardinals recorded 19 total takeaways last season (T19th in the league), failing to perform to the same level as the Chargers, who recorded 23 (T7th).
  • On offense, the Cardinals recorded 21 total giveaways last season (T17th in the league), while the Chargers recorded 21 (T17th).
  • On offense, both teams recorded 21 total giveaways last season (T17th in the league).

First to Score

The Cardinals are +150 to score first, while the Chargers are -195.

  • The Cardinals scored first in nine of their 17 games last season.
  • The Chargers also scored first in nine of their 18 games.

Which team will score the first touchdown?

The Cardinals are +195 to record the first touchdown, while the Chargers are -240.

  • The Cardinals recorded the first touchdown in six of their 17 games last season.
  • The Chargers recorded the first touchdown in eight of their 17 games last season.

First Scoring Play

    Play Frequency Odds
    Arizona Touchdown3 / 17+412
    Arizona Field Goal6 / 17+382
    Arizona Safety0 / 17+7000
    LA Chargers Touchdown5 / 17+127
    LA Chargers Field Goal4 / 17+331
    LA Chargers Safety0 / 17+6600

Which team will get a quick start?

The Cardinals are +214 to be the first team to reach 10 points, while the Chargers are -268.

  • The Cardinals were the first to score 10 points in six of their 17 games last season.
  • The Chargers were the first to score 10 points in eight of their 17 games last season.

First Quarter Moneyline

The Chargers are favored in the 1st Quarter Moneyline market, currently at -238, while the Cardinals are +195.

  • The Cardinals had a 6-6-5 first quarter W/L/T record last season, while the Chargers held a record of 7-9-2.

Last Time They Met

The Cardinals recorded a 17-15 victory over the Chargers at State Farm Stadium when these teams last met in Week 7, 2024.