MLB Prop Bets: Philadelphia Phillies vs Cleveland Guardians (May 22, 2026)
The Cleveland Guardians (30-22) face the Philadelphia Phillies (25-25) at Citizens Bank Park on Friday at 6:40pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Gavin Williams is the probable pitcher for the Guardians, while Cristopher Sanchez is the probable pitcher for the Phillies. The Phillies are favored to win at -185, while the Guardians are at +152. The total runs line is set at 7.0, with OVER at +100 and UNDER at -121.
- The Guardians (-150) have a 27-25 Run Line record this season, while the Phillies (+124) hold a record of 16-34.
- The Guardians have a 26-26-0 O/U record this season (meaning 26 games have gone over the total runs line and 26 have gone under). The Phillies have a 24-24-2 O/U record.
Scoring Insights
- The Guardians are averaging 4.4 runs per game this season (15th in the league). Comparatively, the Phillies are averaging 4.2 (19th).
- In the field, the Guardians are allowing 3.9 runs per game this season (8th in the league), while the Phillies are allowing an average of 4.7 runs (22nd).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the Guardians are at .230 (ranking 26th in the Major leagues), while the Phillies are batting .231 (25th).
Home Runs
- In terms of total home runs this season, the Phillies have hit 62 (6th in the Major Leagues). Meanwhile, the Guardians have managed 53 (16th).
Runs Batted In
- Finally, looking at their runs batted in, the Guardians have recorded 218 RBIs to rank T9th in the MLB this season. Comparatively, the Phillies have recorded 205 RBIs to rank T19th.
Pitching Insights:
Earned Run Average
- The Phillies have an earned run average of 4.31 this season (22nd in the Majors), while The Guardians have an ERA of 3.67 (8th).
Strikeouts
- Turning our attention to total strikeouts, the Guardians have recorded 484 this season, ranking 1st in the MLB. Meanwhile, the Phillies rank 2nd for total strikeouts, recording 476.
Opponent Batting Average
- Opponents are batting an average of .265 against the Phillies this season (29th in the Major Leagues). Comparatively, the Guardians' opponents are at .234 (10th).
First Innings Moneyline
- Here are their first innings moneyline records in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Guardians | 11-8-33 | 6-3-16 | 5-5-17 | 6-5-18 | 5-3-15 | 0-0-0 | 2-1-7 |
| Phillies | 16-12-22 | 10-7-10 | 6-5-12 | 14-9-13 | 2-3-9 | 0-0-0 | 5-0-5 |
Lead After Three Innings
- Here are their records after the first three innings in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Guardians | 22-16-14 | 12-6-7 | 10-10-7 | 12-7-10 | 10-9-4 | 0-0-0 | 7-2-1 |
| Phillies | 18-22-10 | 12-12-3 | 6-10-7 | 15-16-5 | 3-6-5 | 0-0-0 | 4-2-4 |
NRFI/YRFI
The NRFI market is paying -135 and the YRFI is paying +105.
- The NRFI is 30-22 in Guardians games this season. The Phillies have a 22-28 NRFI record.
Last Time They Met
The Phillies recorded an upset 3-0 victory over the Guardians at Progressive Field when these teams last met on May 11, 2025. Kyle Schwarber was crushing the ball in that matchup, hitting 2 home runs and recording 3 RBIs.
