MLB Prop Bets: San Francisco Giants vs Chicago White Sox (May 22, 2026)
The Chicago White Sox (25-24) face the San Francisco Giants (20-30) at Oracle Park on Friday at 10:15pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Davis Martin is the probable pitcher for the White Sox, while Trevor McDonald is the probable pitcher for the Giants. The White Sox are favored to win at -114, while the Giants are at -105. The total runs line is set at 7.0, with OVER at -117 and UNDER at -103.
- The White Sox (+153) have a 27-22 Run Line record this season, while the Giants (-186) hold a record of 22-28.
- The White Sox have a 28-20-1 O/U record this season (meaning 28 games have gone over the total runs line, 20 have gone under and one has resulted in a push). The Giants have a 22-26-2 O/U record.
Scoring Insights
- The White Sox are averaging 4.4 runs per game this season (13th in the league). Comparatively, the Giants are averaging only 3.5 (30th).
- In the field, the White Sox are allowing 4.7 runs per game this season (23rd in the league), while the Giants are allowing an average of 4.5 runs (17th).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the White Sox are at .235 (ranking 20th in the Major leagues), while the Giants are batting .244 (11th).
Home Runs
- In terms of total home runs this season, the White Sox are one of the best in the Major Leagues, hitting 68 to rank 3rd. Alternatively, the Giants are at the opposite end of the home run standings, hitting just 41 (T27th).
Runs Batted In
- Finally, looking at their runs batted in, the White Sox have recorded 207 RBIs to rank 18th in the MLB this season. Comparatively, the Giants have recorded 167 RBIs to rank 30th.
Pitching Insights:
Earned Run Average
- The Giants have an earned run average of 4.15 this season (16th in the Majors), while The White Sox have an ERA of 4.35 (23rd).
Strikeouts
- Turning our attention to total strikeouts, the White Sox have recorded 395 this season, ranking 23rd in the MLB. Meanwhile, the Giants rank 24th for total strikeouts, recording 390.
Opponent Batting Average
- Opponents are batting an average of .246 against the Giants this season (21st in the Major Leagues). Comparatively, the White Sox's opponents are at .239 (15th).
First Innings Moneyline
- Here are their first innings moneyline records in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| White Sox | 14-12-23 | 7-6-11 | 7-6-12 | 0-1-5 | 14-11-18 | 0-0-0 | 2-6-2 |
| Giants | 9-12-29 | 5-3-14 | 4-9-15 | 2-3-9 | 7-9-20 | 0-0-0 | 1-4-5 |
Lead After Three Innings
- Here are their records after the first three innings in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| White Sox | 21-16-12 | 11-7-6 | 10-9-6 | 0-3-3 | 21-13-9 | 0-0-0 | 3-5-2 |
| Giants | 16-24-10 | 6-10-6 | 10-14-4 | 3-7-4 | 13-17-6 | 0-0-0 | 4-6-0 |
NRFI/YRFI
The NRFI market is paying -140 and the YRFI is paying +110.
- The NRFI is 22-27 in White Sox games this season. The Giants have a 28-22 NRFI record.
Last Time They Met
The White Sox recorded an upset 5-2 victory over the Giants at Rate Field when these teams last met on June 29, 2025. Kyle Teel went yard en route to that victory, hitting a home run to go with 2 RBIs.
