MLB Prop Bets: San Diego Padres vs Athletics (May 22, 2026)
The Athletics (26-24) face the San Diego Padres (29-20) at Petco Park on Friday at 9:40pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Jeffrey Springs is the probable pitcher for the Athletics, while Walker Buehler is the probable pitcher for the Padres. The Padres are favored to win at -136, while the Athletics are at +113. The total runs line is set at 8.0, with OVER at -110 and UNDER at -110.
- The Athletics (-186) have a 28-22 Run Line record this season, while the Padres (+153) hold a record of 25-24.
- The Athletics have a 23-24-3 O/U record this season (meaning 23 games have gone over the total runs line, 24 have gone under and three have resulted in a push). The Padres have a 21-27-1 O/U record.
Scoring Insights
- The Athletics are averaging 4.5 runs per game this season (11th in the league). Comparatively, the Padres are averaging only 4.1 (22nd).
- In the field, the Athletics are allowing 4.6 runs per game this season (18th in the league), while the Padres are allowing an average of 4.0 runs (10th).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the Athletics are at an impressive .249 (ranking 5th in the Major leagues), while the Padres are batting an underwhelming .221 (30th).
Home Runs
- In terms of total home runs this season, the Padres have hit 49 (18th in the Major Leagues). Meanwhile, the Athletics have managed 54 (T14th).
Runs Batted In
- Finally, looking at their runs batted in, the Athletics have recorded 220 RBIs to rank 8th in the MLB this season. Comparatively, the Padres have recorded 193 RBIs to rank 25th.
Pitching Insights:
Earned Run Average
- The Padres have an earned run average of 3.93 this season (13th in the Majors), while The Athletics have an ERA of 4.26 (20th).
Strikeouts
- Turning our attention to total strikeouts, the Athletics have recorded 396 this season, ranking 22nd in the MLB. Meanwhile, the Padres rank 13th for total strikeouts, recording 426.
Opponent Batting Average
- Opponents are batting an average of .234 against the Padres this season (11th in the Major Leagues). Comparatively, the Athletics' opponents are at .252 (24th).
First Innings Moneyline
- Here are their first innings moneyline records in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Athletics | 10-15-25 | 4-8-10 | 6-7-15 | 3-6-7 | 7-9-18 | 0-0-0 | 1-3-6 |
| Padres | 7-8-34 | 5-4-17 | 2-4-15 | 5-3-18 | 2-5-16 | 0-0-2 | 2-2-6 |
Lead After Three Innings
- Here are their records after the first three innings in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Athletics | 21-18-11 | 8-9-5 | 13-9-6 | 4-8-4 | 17-10-7 | 0-0-0 | 3-5-2 |
| Padres | 12-21-16 | 8-11-7 | 3-9-9 | 5-10-11 | 7-11-5 | 1-1-0 | 4-3-3 |
NRFI/YRFI
The NRFI market is paying -105 and the YRFI is paying -120.
- The NRFI is 23-27 in Athletics games this season. The Padres have a 33-16 NRFI record.
Last Time They Met
The Padres recorded a 2-1 victory over the Athletics at Sutter Health Park when these teams last met on April 9, 2025. Xander Bogaerts led the way to that victory, hitting a home run.
