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MLB Prop Bets: St. Louis Cardinals vs Chicago Cubs (July 28, 2026)

The Chicago Cubs (60-46) face the St. Louis Cardinals (53-53) at Busch Stadium on Tuesday at 7:45pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Colin Rea is the probable pitcher for the Cubs, while Michael McGreevy is the probable pitcher for the Cardinals. The Cubs are favored to win at -115, while the Cardinals are at -105. The total runs line is set at 9.0, with OVER at +100 and UNDER at -120.

  • The Cubs (+149) have a 49-57 Run Line record this season, while the Cardinals (-181) hold a record of 59-47.
  • The Cubs have a 56-48-2 O/U record this season (meaning 56 games have gone over the total runs line, 48 have gone under and two have resulted in a push). The Cardinals have a 43-59-4 O/U record.

Scoring Insights

  • The Cubs are averaging 5.2 runs per game this season (3rd in the league). Comparatively, the Cardinals are averaging only 4.4 (16th).
  • In the field, the Cubs are allowing 4.4 runs per game this season (12th in the league), while the Cardinals are allowing an average of 4.5 runs (15th).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the Cubs are at .248 (ranking 11th in the Major leagues), while the Cardinals are batting .240 (20th).

Home Runs

  • In terms of total home runs this season, the Cardinals have hit 112 (22nd in the Major Leagues). Meanwhile, the Cubs have managed 133 (10th).

Runs Batted In

  • Finally, looking at their runs batted in, the Cubs have recorded 514 RBIs to rank 3rd in the MLB this season. Comparatively, the Cardinals have recorded 457 RBIs to rank 14th.

Pitching Insights:

Earned Run Average

  • The Cardinals have an earned run average of 4.16 this season (14th in the Majors), while The Cubs have an ERA of 4.22 (17th).

Strikeouts

  • Turning our attention to total strikeouts, the Cubs have recorded 825 this season, ranking 25th in the MLB. Meanwhile, the Cardinals rank 26th for total strikeouts, recording 815.

Opponent Batting Average

  • Opponents are batting an average of .253 against the Cardinals this season (24th in the Major Leagues). Comparatively, the Cubs' opponents are at .246 (18th).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Cubs 24-19-63 16-10-26 8-9-37 22-10-42 2-9-21 0-0-0 6-1-3
    Cardinals 23-19-64 11-9-37 12-10-27 9-6-17 14-13-47 0-0-0 2-2-6

Lead After Three Innings

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Cubs 40-35-31 26-16-10 14-19-21 35-21-18 5-14-13 0-0-0 4-3-3
    Cardinals 46-30-30 25-14-18 21-16-12 17-7-8 29-23-22 0-0-0 5-3-2

NRFI/YRFI

The NRFI market is paying -110 and the YRFI is paying -120.

  • The NRFI is 61-45 in Cubs games this season. The Cardinals have a 56-50 NRFI record.

Last Time They Met

The Cubs recorded a 7-3 victory over the Cardinals at Busch Stadium yesterday. Alex Bregman was unstoppable in that matchup, hitting a home run, a single and recording 2 RBIs.