MLB Prop Bets: St. Louis Cardinals vs Chicago White Sox (September 12, 2026)
The Chicago White Sox (75-72) face the St. Louis Cardinals (73-75) at Busch Stadium on Saturday at 7:15pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Sean Newcomb is the probable pitcher for the White Sox, while Kyle Leahy is the probable pitcher for the Cardinals. The Cardinals are favored to win at -116, while the White Sox are at -104. The total runs line is set at 8.5, with OVER at -105 and UNDER at -115.
- The White Sox (+157) have an 81-66 Run Line record this season, while the Cardinals (-191) hold a record of 81-67.
- The White Sox have an 82-63-2 O/U record this season (meaning 82 games have gone over the total runs line, 63 have gone under and two have resulted in a push). The Cardinals have a 68-74-6 O/U record.
Scoring Insights
- The White Sox are averaging 4.7 runs per game this season (T6th in the league). Comparatively, the Cardinals are averaging 4.6 (11th).
- In the field, the White Sox are allowing 4.4 runs per game this season (15th in the league), while the Cardinals are allowing an average of 4.6 runs (20th).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the White Sox are at .235 (ranking 25th in the Major leagues), while the Cardinals are batting .244 (16th).
Home Runs
- In terms of total home runs this season, the Cardinals have hit 156 (22nd in the Major Leagues). Meanwhile, the White Sox have managed 192 (6th).
Runs Batted In
- Finally, looking at their runs batted in, the White Sox have recorded 657 RBIs to rank 7th in the MLB this season. Comparatively, the Cardinals have recorded 655 RBIs to rank 8th.
Pitching Insights:
Earned Run Average
- The Cardinals have an earned run average of 4.30 this season (21st in the Majors), while The White Sox have an ERA of 4.15 (15th).
Strikeouts
- Turning our attention to total strikeouts, the White Sox have recorded 1211 this season, ranking 17th in the MLB. Meanwhile, the Cardinals rank 24th for total strikeouts, recording 1167.
Opponent Batting Average
- Opponents are batting an average of .255 against the Cardinals this season (26th in the Major Leagues). Comparatively, the White Sox's opponents are at .242 (15th).
First Innings Moneyline
- Here are their first innings moneyline records in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| White Sox | 36-39-72 | 19-18-37 | 17-21-35 | 9-6-26 | 27-33-46 | 0-0-0 | 2-2-6 |
| Cardinals | 32-30-86 | 12-12-49 | 20-18-37 | 12-13-25 | 20-17-61 | 0-0-0 | 1-6-3 |
Lead After Three Innings
The White Sox are -105 to lead after three innings, while the Cardinals are -125.
- Here are their records after the first three innings in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| White Sox | 51-52-44 | 27-23-24 | 24-29-20 | 13-8-20 | 38-44-24 | 0-0-0 | 2-3-5 |
| Cardinals | 64-45-39 | 32-20-21 | 32-25-18 | 26-13-11 | 38-32-28 | 0-0-0 | 6-4-0 |
NRFI/YRFI
- The NRFI is 66-81 in White Sox games this season. The Cardinals have a 76-72 NRFI record.
Last Time They Met
The Cardinals recorded a 7-3 victory over the White Sox at Busch Stadium yesterday. Chase Meidroth was crushing the ball in that matchup, hitting 2 home runs and recording 2 RBIs. The Cardinals have now won four straight against the White Sox.
