MLB Prop Bets: Boston Red Sox vs Cleveland Guardians (September 22, 2026)
The Cleveland Guardians (81-75) face the Boston Red Sox (84-72) at Fenway Park on Tuesday at 6:45pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Parker Messick is the probable pitcher for the Guardians, while Payton Tolle is the probable pitcher for the Red Sox.
- The Guardians have a 75-79-2 O/U record this season (meaning 75 games have gone over the total runs line, 79 have gone under and two have resulted in a push). The Red Sox have a 70-82-4 O/U record.
Scoring Insights
- The Guardians are averaging 4.2 runs per game this season (26th in the league). Comparatively, the Red Sox are averaging 4.3 (20th).
- In the field, the Guardians are allowing 4.1 runs per game this season (8th in the league), while the Red Sox are allowing an average of 3.8 runs (3rd).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the Guardians are at .238 (ranking 24th in the Major leagues), while the Red Sox are batting .246 (12th).
Home Runs
- In terms of total home runs this season, the Red Sox have hit 161 (T23rd in the Major Leagues). Meanwhile, the Guardians have managed 152 (27th).
Runs Batted In
- Finally, looking at their runs batted in, the Guardians have recorded 622 RBIs to rank 26th in the MLB this season. Comparatively, the Red Sox have recorded 648 RBIs to rank 20th.
Pitching Insights:
Earned Run Average
- The Red Sox have an earned run average of 3.59 this season (3rd in the Majors), while The Guardians have an ERA of 3.78 (8th).
Strikeouts
- Turning our attention to total strikeouts, the Guardians have recorded 1476 this season, ranking 3rd in the MLB. Meanwhile, the Red Sox rank 11th for total strikeouts, recording 1352.
Opponent Batting Average
- Opponents are batting an average of .241 against the Red Sox this season (15th in the Major Leagues). Comparatively, the Guardians' opponents are at .236 (8th).
First Innings Moneyline
- Here are their first innings moneyline records in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Guardians | 36-27-93 | 21-14-46 | 15-13-47 | 25-18-57 | 11-9-36 | 0-0-0 | 4-1-5 |
| Red Sox | 32-43-81 | 18-18-39 | 14-25-42 | 23-28-57 | 9-15-24 | 0-0-0 | 1-3-6 |
Lead After Three Innings
- Here are their records after the first three innings in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Guardians | 56-52-48 | 35-25-21 | 21-27-27 | 39-33-28 | 17-19-20 | 0-0-0 | 4-4-2 |
| Red Sox | 65-59-32 | 36-27-12 | 29-32-20 | 49-37-22 | 16-22-10 | 0-0-0 | 4-5-1 |
NRFI/YRFI
- The NRFI is 87-69 in Guardians games this season. The Red Sox have a 75-81 NRFI record.
Last Time They Met
The Red Sox recorded a 9-4 victory over the Guardians at Progressive Field when these teams last met on May 31. Jarren Duran went yard en route to that victory, hitting a home run to go with an RBI.
